ArticleBMJ open diabetes research & care2020
Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study.
Article in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Risk factors associated with mortality in individuals with type 2 diabetes following an episode of severe hypoglycaemia. Results from a randomised controlled trial.Diabetes & vascular disease researchTrial
- Diabetes progression and severe hypoglycemia: a nationwide cohort study of 2,475,605 adults with type 2 diabetes mellitus.The Korean journal of internal medicine · 2026Article
- Diabetes progression and its association with fracture risk in type 2 diabetes.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Distinct Circulating Biomarker Profiles Associated with Type 2 Diabetes in a Regional Cohort-A Cross-Sectional Study.Metabolites · 2025Article
- Glucagon-like peptide 1 receptor agonist and reduced liver and non-liver complications in adults with type 2 diabetes and metabolic dysfunction-associated steatotic liver disease: a target trial emulation study.Clinical and molecular hepatology · 2025Article
- Development of a Claims-Based Computable Phenotype for Ulcerative Colitis Flares.medRxiv : the preprint server for health sciences · 2025Article
- Depression screening model for middle-aged and elderly diabetic patients in China.Scientific reports · 2024Article
- Patient portal registration and healthcare utilisation in general practices in England: a longitudinal cohort study.BJGP open · 2024Article
- Article
- A nationwide cohort study on diabetes severity and risk of Parkinson disease.NPJ Parkinson's disease · 2023Article
- Profiling of patients with type 2 diabetes based on medication adherence data.Frontiers in public health · 2023Article
- Association between dysglycemia and the Charlson Comorbidity Index among hospitalized patients with diabetes.Journal of diabetes and its complications · 2022Article
- Development and Validation of a Nomogram to Predict Type 2 Diabetes Mellitus in Overweight and Obese Adults: A Prospective Cohort Study from 82938 Adults in China.International journal of endocrinology · 2020Article
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16 authors.
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Abstract
objectiveClinically applicable diabetes severity measures are lacking, with no previous studies comparing their predictive value with glycated hemoglobin (HbA RESEARCH DESIGN AND
methodsWe used UK primary and secondary care data for 139 626 individuals with type 2 diabetes between 2007 and 2017, aged ≥35 years, and registered in general practices in England. The study cohort was randomly divided into a training cohort (n=111 748, 80%) to develop the severity tool and a validation cohort (n=27 878). We developed baseline and longitudinal severity scores using 34 diabetes-related domains. Cox regression models (adjusted for age, gender, ethnicity, deprivation, and HbA
resultsA total of 139 626 patients registered in 400 general practices, aged 63±12 years were included, 45% of whom were women, 83% were White, and 18% were from deprived areas. The mean baseline severity score was 1.3±2.0. Overall, 27 362 (20%) people died and 99 951 (72%) had ≥1 hospitalization. In the training cohort, a one-unit increase in baseline DISSCO was associated with higher hazard of mortality (HR: 1.14, 95% CI 1.13 to 1.15, area under the receiver operating characteristics curve (AUROC)=0.76) and cardiovascular hospitalization (HR: 1.45, 95% CI 1.43 to 1.46, AUROC=0.73). The LR tests showed that adding DISSCO to sociodemographic variables significantly improved the predictive value of survival models, outperforming the added value of HbA
conclusionsHigher levels of DISSCO are associated with higher risks for hospital admissions and mortality. The new severity score had higher predictive value than the proxy used in clinical practice, HbA
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