Evidence map›Paper›PMID 32385045›Full record

ArticleG3 (Bethesda, Md.)2020

The Gene

Kathryn S Evans, Erik C Andersen

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Natural variation suggests candidate genes underlying Caenorhabditis elegans susceptibility to diverse toxicants.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Article
  3. Natural variation suggests candidate genes underlyingbioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. The regulatory architecture of gene expression variation inbioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Benzimidazoles cause lethality by inhibiting the function of Caenorhabditis elegans neuronal beta-tubulin.International journal for parasitology. Drugs and drug resistance · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kathryn S EvansMolecular Biosciences, Northwestern University, Evanston, IL 60208.ORCID 0000-0002-1388-8155
Erik C AndersenMolecular Biosciences, Northwestern University, Evanston, IL 60208 erik.andersen@northwestern.edu.ORCID 0000-0003-0229-9651
Northwestern University · US

Funding

CELLULAR &MOLECULAR BASIS OF DISEASE TRAINING PROGRAMT32GM008061 · NIGMS · NORTHWESTERN UNIVERSITY · PI CARTHEW, RICHARD W. · 1985 to 2022
$17.1M
Discovery of conserved molecular mechanisms underlying population-wide variation in toxin responsesR01ES029930 · NIEHS · NORTHWESTERN UNIVERSITY · PI ANDERSEN, ERIK CHRISTIAN, BAUGH, LARRY RYAN · 2019 to 2023
$3.2M
NIEHS NIH HHS R01 ES029930NIGMS NIH HHS T32 GM008061
6 · The paper itself

Abstract

Pleiotropy, the concept that a single gene controls multiple distinct traits, is prevalent in most organisms and has broad implications for medicine and agriculture. The identification of the molecular mechanisms underlying pleiotropy has the power to reveal previously unknown biological connections between seemingly unrelated traits. Additionally, the discovery of pleiotropic genes increases our understanding of both genetic and phenotypic complexity by characterizing novel gene functions. Quantitative trait locus (QTL) mapping has been used to identify several pleiotropic regions in many organisms. However, gene knockout studies are needed to eliminate the possibility of tightly linked, non-pleiotropic loci. Here, we use a panel of 296 recombinant inbred advanced intercross lines of

Indexed as

Caenorhabditis elegansNematodaAnimalsCaenorhabditis elegans ProteinsChromosome MappingNuclear ProteinsPhenotypeQuantitative Trait LociCaenorhabditis elegans ProteinsNuclear Proteinsscb-1 protein, C elegansC. eleganschemotherapeuticsmediationpleiotropyQTL

Identifiers

PMID32385045
PMCPMC7341127
OpenAlexW3021811794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.