Evidence map›Paper›PMID 32384902›Full record

SynthesisLipids in health and disease2020

Effects of fish oil supplementation on glucose control and lipid levels among patients with type 2 diabetes mellitus: a Meta-analysis of randomized controlled trials.

Chao Gao, Yang Liu, Yong Gan, Wei Bao, Xiaolin Peng, Qingbin Xing, Huiyu Gao, Jianqiang Lai, Liegang Liu, Zhu Wang and 1 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Lipids in health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 6 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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  19. Processing Alaska Pollock Protein (Foods (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Chao GaoKey Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No 29 Nanwei Road, Beijing, 100050, China.
Yang LiuKey Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No 29 Nanwei Road, Beijing, 100050, China.
Yong GanSchool of Public Health, Tongji Medical College, Ministry of Education Key Laboratory of Environment, Hubei Key Laboratory of Food Nutrition and Safety, Huazhong University of Science and Technology, Wuhan, 430030, China.
Wei BaoDepartment of Epidemiology, College of Public Health, Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa, 52242, USA.
Xiaolin PengShenzhen Nanshan Center for Chronic Disease Control, Shenzhen, 518000, China.
Qingbin XingKey Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No 29 Nanwei Road, Beijing, 100050, China.
Huiyu GaoKey Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No 29 Nanwei Road, Beijing, 100050, China.
Jianqiang LaiKey Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No 29 Nanwei Road, Beijing, 100050, China.
Liegang LiuSchool of Public Health, Tongji Medical College, Ministry of Education Key Laboratory of Environment, Hubei Key Laboratory of Food Nutrition and Safety, Huazhong University of Science and Technology, Wuhan, 430030, China.
Zhu WangKey Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No 29 Nanwei Road, Beijing, 100050, China.
Yuexin YangKey Laboratory of Trace Element Nutrition of National Health Commission, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, No 29 Nanwei Road, Beijing, 100050, China. yxyang@263.net.
Huazhong University of Science and Technology · CNFraternal Order of Eagles · USShenzhen Nanshan Center for Chronic Disease Control · CN

Funding

2015 Chinese Nutrition Society (CNS) Nutrition Research Foundation-DSM Research Fund CNS2015067BNational Natural Science Foundation of China No.81602858Young Elite Scientists Sponsorship Program by CAST No.YESS20160164, 2016QNRC001
6 · The paper itself

Abstract

backgroundPrevious studies have yielded inconsistent findings on the role of fish oil in type 2 diabetes mellitus (T2DM). We systematically summarized the available evidence from randomized controlled trials (RCT) and aimed to investigate the effects of fish oil supplementation on glucose control and lipid levels among patients with T2DM.

methodsA comprehensive literature search was performed in electronic databases (PubMed, ProQuest, Cochrane Library, CNKI, VIP, and Wanfang) to identify all relevant RCTs which were published up to May 31st, 2019. We used Modified Jadad Score system to evaluate the quality of each included RCT. The pooled effects were estimated using random-effects model and presented as standardized mean differences with 95% confidence intervals.

resultsA total of 12 RCTs were included in this meta-analysis. There was no significant difference in glucose control outcomes comparing fish oil supplementation to placebo. The effect size of fasting plasma glucose (FPG) was 0.13 (95% CI: - 0.03 to 0.28, p > 0.05). No marked change was observed in fasting insulin (FINS), glycosylated hemoglobin (HbA1c), and HOMA of insulin resistance (HOMA-IR) levels. Fish oil supplementation was associated with a decrease of triglyceride (TG) level by - 0.40 (95%CI: - 0.53 to - 0.28, p < 0.05), and an increase of high density lipoprotein (HDL) cholesterol level by 0.21 (95%CI: 0.05 to 0.37, p < 0.05). In subgroup analysis, HDL cholesterol level was higher among Asian and low-dose(< 2 g/d n-3 PUFA) subgroups compared to their counterparts (p < 0.05). TG level was lower in mid and long duration groups, along with an inconspicuous difference in short duration group.

conclusionsThis meta-analysis shows that among patients with T2DM, fish oil supplementation leads to a favorable blood lipids profile but does not improve glucose control.

Indexed as

Dietary SupplementsAdultAgedBlood GlucoseCholesterol, HDLCholesterol, LDLDiabetes Mellitus, Type 2FastingFemaleFish OilsGlycated HemoglobinHumansInsulinInsulin ResistanceMaleMiddle AgedBlood GlucoseCholesterol, HDLCholesterol, LDLFish OilsGlycated Hemoglobinhemoglobin A1c protein, humanInsulinTriglyceridesFish oilMeta-analysisOmega-3 fatty acidsRandomized clinical trialsType 2 diabetes mellitus

Identifiers

PMID32384902
PMCPMC7206824
OpenAlexW3023974360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.