Evidence map›Paper›PMID 32384765›Full record

ArticleInternational journal of environmental research and public health2020

Particulate Matter Decreases Intestinal Barrier-Associated Proteins Levels in 3D Human Intestinal Model.

Brittany Woodby, Maria Lucia Schiavone, Erika Pambianchi, Angela Mastaloudis, Shelly N Hester, Steven M Wood, Alessandra Pecorelli, Giuseppe Valacchi

Open access · goldAbstract read
In one paragraph

Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Brittany WoodbyPlants for Human Health Institute, Animal Sciences Dept., NC Research Campus Kannapolis, State University, Kannapolis, NC 28081 USA.ORCID 0000-0002-9518-9410
Maria Lucia SchiavonePlants for Human Health Institute, Animal Sciences Dept., NC Research Campus Kannapolis, State University, Kannapolis, NC 28081 USA.
Erika PambianchiPlants for Human Health Institute, Animal Sciences Dept., NC Research Campus Kannapolis, State University, Kannapolis, NC 28081 USA.ORCID 0000-0002-8843-0560
Angela MastaloudisPharmanex Research, NSE Products, Inc., Provo, UT 84601, USA.ORCID 0000-0001-8504-9900
Shelly N HesterPharmanex Research, NSE Products, Inc., Provo, UT 84601, USA.ORCID 0000-0002-2679-0886
Steven M WoodPharmanex Research, NSE Products, Inc., Provo, UT 84601, USA.
Alessandra PecorelliPlants for Human Health Institute, Animal Sciences Dept., NC Research Campus Kannapolis, State University, Kannapolis, NC 28081 USA.ORCID 0000-0002-5207-068X
Giuseppe ValacchiPlants for Human Health Institute, Animal Sciences Dept., NC Research Campus Kannapolis, State University, Kannapolis, NC 28081 USA.
David H. Murdock Research Institute · USNuvOx Pharma (United States) · USUniversity of Ferrara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: The gastrointestinal tract (GI) tract is one of the main organs exposed to particulate matter (PM) directly through ingestion of contaminated food or indirectly through inhalation. Previous studies have investigated the effects of chronic PM exposure on intestinal epithelia in vitro using Caco-2 cells and in vivo using mice. In this study, we hypothesized that chronic PM exposure would increase epithelial permeability and decrease barrier function due to altered redox homeostasis, which alters levels and/or localization of barrier-associated proteins in human three-dimensional (3D) intestinal tissues. (2) Methods: Transepithelial electrical resistance (TEER) in tissues exposed to 50, 100, 150, 250, and 500 µg/cm

Indexed as

Caco-2 CellsAnimalsGastrointestinal TractHumansIntestinal MucosaIntestinesMembrane ProteinsMiceOxidation-ReductionParticulate MatterTight Junction ProteinsTight JunctionsMembrane ProteinsParticulate MatterTight Junction Proteins4HNEdesmosomepollutiontight junctionsZO−1

Identifiers

PMID32384765
PMCPMC7246573
OpenAlexW3022395614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.