Evidence map›Paper›PMID 32384752›Full record

ArticlePharmaceutics2020

In Vitro Performance and Chemical Stability of Lipid-Based Formulations Encapsulated in a Mesoporous Magnesium Carbonate Carrier.

Caroline Alvebratt, Tahnee J Dening, Michelle Åhlén, Ocean Cheung, Maria Strømme, Adolf Gogoll, Clive A Prestidge, Christel A S Bergström

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Caroline AlvebrattDepartment of Pharmacy, Uppsala Biomedical Centre P.O. Box 580, Uppsala University, SE-751 23, Uppsala, Sweden.
Tahnee J DeningUniversity of South Australia, UniSA: Clinical and Health Sciences, Adelaide SA 5000, Australia.
Michelle ÅhlénDivision of Nanotechnology and Functional Materials, Department of Engineering Sciences, Uppsala University, SE-75121 Uppsala, Sweden.
Ocean CheungDivision of Nanotechnology and Functional Materials, Department of Engineering Sciences, Uppsala University, SE-75121 Uppsala, Sweden.
Maria StrømmeDivision of Nanotechnology and Functional Materials, Department of Engineering Sciences, Uppsala University, SE-75121 Uppsala, Sweden.
Adolf GogollDepartment of Chemistry -Biomedical Centre P.O. Box 576, Uppsala University, Uppsala SE-751 23, Sweden.
Clive A PrestidgeUniversity of South Australia, UniSA: Clinical and Health Sciences, Adelaide SA 5000, Australia.
Christel A S BergströmDepartment of Pharmacy, Uppsala Biomedical Centre P.O. Box 580, Uppsala University, SE-751 23, Uppsala, Sweden.
Uppsala University · SEUniversity of South Australia · AU

Funding

Familjen Erling-Perssons Stiftelse 2017The Australian Award Endeavour Scholarships and Fellowships Program ID: 6675_2018Vetenskapsrådet 2014-3929
6 · The paper itself

Abstract

Lipid-based formulations can circumvent the low aqueous solubility of problematic drug compounds and increase their oral absorption. As these formulations are often physically unstable and costly to manufacture, solidification has been suggested as a way to minimize these issues. This study evaluated the physicochemical stability and in vitro performance of lipid-loaded mesoporous magnesium carbonate (MMC) particles with an average pore size of 20 nm. A medium chain lipid was loaded onto the MMC carrier via physical adsorption. A modified in vitro lipolysis setup was then used to study lipid release and digestion with

Indexed as

1H nuclear magnetic resonancelipid-based formulationslipid releaselipolysismesoporous magnesium carbonatesolidification

Identifiers

PMID32384752
PMCPMC7284621
OpenAlexW3023706202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.