Evidence map›Paper›PMID 32384696›Full record

ArticleInternational journal of molecular sciences2020

Infusion of Plasma from Exercised Mice Ameliorates Cognitive Dysfunction by Increasing Hippocampal Neuroplasticity and Mitochondrial Functions in 3xTg-AD Mice.

Tae-Woon Kim, Sang-Seo Park, Joon-Young Park, Hye-Sang Park

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
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  4. Physical activity, falls, and dementia risk in adults aged ≥ 60: evidence from three cohorts.The international journal of behavioral nutrition and physical activity · 2026
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  10. The relationship between adult hippocampal neurogenesis and cognitive impairment in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Tae-Woon KimExercise Rehabilitation Research Institute, Department of Exercise & Health Science, Sangmyung University, Seoul 03016, Korea.ORCID 0000-0001-8832-0874
Sang-Seo ParkDepartment of Physiology, College of Medicine, KyungHee University, Seoul 02447, Korea.
Joon-Young ParkDepartment of Kinesiology, College of Public Health and Cardiovascular Research Center, Lewis Katz school of Medicine, Temple University, Philadelphia, PA 19122, USA.
Hye-Sang ParkDepartment of Kinesiology, College of Public Health and Cardiovascular Research Center, Lewis Katz school of Medicine, Temple University, Philadelphia, PA 19122, USA.
Temple University · USKyung Hee University · KRSangmyung University · KR

Funding

Functional implications of fluid shear stress-induced mitochondrial remodelingR01HL126952 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI PARK, JOON YOUNG · 2015 to 2019
$2.1M
National Research Foundation of Korea NRF-2017S1A5A2A01024208NHLBI NIH HHS R01 HL126952
6 · The paper itself

Abstract

Alzheimer's disease is the most common neurodegenerative brain disease causing dementia. It is characterized by slow onset and gradual worsening of memory and other cognitive functions. Recently, parabiosis and infusion of plasma from young mice have been proposed to have positive effects in aging and Alzheimer's disease. Therefore, this study examined whether infusion of plasma from exercised mice improved cognitive functions related to the hippocampus in a 3xTg-Alzheimer's disease (AD) model. We collected plasma from young mice that had exercised for 3 months and injected 100 µL of plasma into the tail vein of 12-month-old 3xTg-AD mice 10 times at 3-day intervals. We then analyzed spatial learning and memory, long-term memory, hippocampal GSK3β/tau proteins, synaptic proteins, mitochondrial function, apoptosis, and neurogenesis. In the hippocampus of 3xTg-AD mice, infusion of plasma from exercised mice improved neuroplasticity and mitochondrial function and suppressed apoptosis, ultimately improving cognitive function. However, there was no improvement in tau hyperphosphorylation. This study showed that plasma from exercised mice could have a protective effect on cognitive dysfunction and neural circuits associated with AD via a tau-independent mechanism involving elevated brain-derived neurotrophic factor due to exercise.

Indexed as

AnimalsApoptosisCognitive DysfunctionGlycogen Synthase Kinase 3 betaHippocampusMaleMiceMice, Inbred C57BLMitochondriaNeuronal PlasticityPhysical Conditioning, AnimalPlasma Exchangetau ProteinsGlycogen Synthase Kinase 3 betatau ProteinsAlzheimer’s diseasecognitive functionexercisehippocampusmitochondrianeuroplasticityyoung plasma

Identifiers

PMID32384696
PMCPMC7247545
OpenAlexW3023148756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.