ArticleJPEN. Journal of parenteral and enteral nutrition2021
Early Lipid Intake Improves Cerebellar Growth in Very Low-Birth-Weight Preterm Infants.
Article in JPEN. Journal of parenteral and enteral nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Randomized Trial of Early Enhanced Parenteral Nutrition and Later Neurodevelopment in Preterm Infants.Nutrients · 2022Trial
- Donor human milk and structural brain development in very preterm infants.Pediatric research · 2026Observational
- Early parenteral lipid intake supports cerebellar neurometabolism at term-age in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2025Observational
- Impact of early nutrition on brain development and neurocognitive outcomes in very preterm infants.Pediatric research · 2025Article
- Essential fatty acid deficiency in parenteral nutrition: Historical perspective and modern solutions, a narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025Review
- Brain development using a multicomponent intravenous lipid emulsion in preterm infants.BMC pediatrics · 2024Article
- Quantitative Evaluation of White Matter Injury by Cranial Ultrasound to Detect the Effects of Parenteral Nutrition in Preterm Babies: An Observational Study.Journal of imaging · 2024Article
- Maternal milk in the NICU: An everyday intervention to improve brain development.Pediatric research · 2024Article
- Aging, Neurodegenerative Disorders, and Cerebellum.International journal of molecular sciences · 2024Review
- Improving growth in preterm infants through nutrition: a practical overview.Frontiers in nutrition · 2024Review
- Associations of Macronutrient Intake Determined by Point-of-Care Human Milk Analysis with Brain Development among very Preterm Infants.Children (Basel, Switzerland) · 2022Article
- Using Nature to Nurture: Breast Milk Analysis and Fortification to Improve Growth and Neurodevelopmental Outcomes in Preterm Infants.Nutrients · 2021Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundDespite recent advances in nutrition practice in the neonatal intensive care unit, infants remain at high risk for growth restriction following preterm birth. Additionally, optimal values for macronutrient administration, especially lipid intake, have yet to be established for preterm infants in the extrauterine environment.
methodsWe studied preterm infants born at very low-birth weight (VLBW, <1500 g) and ≤32 weeks' gestation. Cumulative macronutrient (carbohydrate, lipid, protein, energy) intake in the first 2 and 4 weeks of life was compared with total and regional brain volumes on magnetic resonance imaging (MRI) obtained at term-equivalent age. Preterm infants had no structural brain injury on conventional MRI.
resultsIn a cohort of 67 VLBW infants, cumulative lipid intake in the first 2 weeks of life was positively associated with significantly greater cerebellar volume (β = 95.8; P = .01) after adjusting for weight gain, gestational age at birth, and postmenstrual age at MRI. Cumulative lipid (β = 36.1, P = .01) and energy (β = 3.1; P = .02) intake in the first 4 weeks of life were both significantly associated with greater cerebellar volume. No relationship was seen between carbohydrate or protein intake in the first month of life and cerebral volume at term-equivalent age.
conclusionEarly cumulative lipid intake in the first month of life is associated with significantly greater cerebellar volume by term-equivalent age in very premature infants. Our findings emphasize the importance of early, aggressive nutrition interventions to optimize cerebellar development in VLBW infants.
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