Evidence map›Paper›PMID 32383801›Full record

Trial reportBritish journal of clinical pharmacology2020

Effectiveness of a multicomponent pharmacist intervention at hospital discharge for drug-related problems: A cluster randomised cross-over trial.

Xavier Pourrat, Clémence Leyrat, Benoît Allenet, Brigitte Bouzige, Armelle Develay, Martial Fraysse, Valérie Garnier, Jean-Michel Halimi, Clarisse Roux-Marson, Bruno Giraudeau

Open access · bronzeAbstract readRandomized Controlled TrialEquivalence Trial
In one paragraph

Trial report in British journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

Xavier PourratPharmacy Department, CHRU de Tours, Tours, France.ORCID 0000-0002-3936-8481
Clémence LeyratDepartment of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.
Benoît AllenetPharmacy Department, CHU de Grenoble, Grenoble, France; ThEMAS TIMC-IMAG (UMR CNRS 5525), J Fourier University, Grenoble, France.
Brigitte BouzigePharmacy Bouzige, 32 rue du pont, Les Salles du Gardon, 30110, France.
Armelle DevelayPharmacy Department, CHU de Nîmes, Nîmes, France.
Martial FrayssePharmacy Fraysse, 52 Rue du Commandant Jean Duhail, Fontenay-sous-Bois, 94120, France.
Valérie GarnierPharmacie Garnier, 1 Chemin des Prés, Meynes, 30840, France.
Jean-Michel HalimiNephrology Department, CHRU de Tours, Tours, France.
Clarisse Roux-MarsonPharmacy Department, CHU de Nîmes, Nîmes, France, Laboratory of Biostatistics, Epidemiology, Clinical Research and Health Economics, EA 2415, University Institute of Clinical Research, Montpellier University, Montpellier, France.
Bruno GiraudeauINSERM CIC1415, CHRU de Tours, Tours, France; Université de Tours, Université de Nantes, INSERM, SPHERE U1246, Tours, France.
Centre Hospitalier Universitaire de Tours · FRCentre Hospitalier Universitaire de Nîmes · FRCentre National de la Recherche Scientifique · FRDuPont (France) · FRLondon School of Hygiene & Tropical Medicine · GBSofradir (France) · FRUniversité de Montpellier · FRUniversité de Tours · FR

Funding

French Ministry of Health PREPS 12-010-0054
6 · The paper itself

Abstract

aimsThe aim of this study was to assess whether a pharmacist intervention associating medication reconciliation at discharge with a link to the community pharmacist reduces drug-related problems (DRP) in adult patients during the 7 days after hospital discharge in 22 university or general hospitals in France.

methodsWe conducted a cluster randomised cross-over superiority trial with hospital units as the cluster unit. The primary outcome was a composite of any kind of DRP (prescription/dispensation, patient error or gap due to no medication available) during the 7 days after discharge, assessed by phone with the patient and community pharmacist. Among secondary outcomes, we studied self-reported unplanned hospitalisations at day 35 after discharge and severe iatrogenic problems.

resultsA total of 1092 patients were enrolled in 48 units (538 in the experimental periods and 554 in the control periods). Three patients refused to have their data analysed and were excluded from the analyses. As compared with usual care, the pharmacist intervention led to a lower proportion of patients with at least one DRP (44.0% vs 50.6%; odds ratio [OR] 0.77, 95% confidence interval [CI] 0.61-0.98) and severe iatrogenic problems (5.2% vs 8.7%; OR 0.57, 95% CI 0.35-0.93) but no significant difference in unplanned hospitalisations at day 35 (5.8% vs 4.5%; OR 1.46, 95% CI 0.91-2.35).

conclusionMedication reconciliation associated with communication between the hospital and community pharmacist may decrease patient exposure to DRP and severe iatrogenic problems but not unplanned hospitalisation. However, this intervention could be recommended in health policies to improve drug management.

Indexed as

Medication ReconciliationPatient DischargePharmacistsPharmacy Service, HospitalCross-Over StudiesFemaleFranceHospitalsHumansMaleMiddle AgedPharmaceutical PreparationsPharmaceutical Preparationscluster randomised cross-over trialcommunicationcommunity pharmacistdrug-related problemhospital dischargehospital pharmacistmedication reconciliation

Identifiers

PMID32383801
PMCPMC7688527
OpenAlexW3022024331

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.