Evidence map›Paper›PMID 32383301›Full record

ArticleJournal of cutaneous pathology2020

Factors associated with use of immunohistochemical markers in the histopathological diagnosis of cutaneous melanocytic lesions.

Caitlin J May, Michael W Piepkorn, Stevan R Knezevich, David E Elder, Raymond L Barnhill, Annie C Lee, Martiniano J Flores, Kathleen F Kerr, Lisa M Reisch, Joann G Elmore

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cutaneous pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Caitlin J MayDermatopathology Northwest, Bellevue, Washington, USA.
Michael W PiepkornDermatopathology Northwest, Bellevue, Washington, USA.
Stevan R KnezevichPathology Associates, Clovis, California, USA.
David E ElderDepartment of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Raymond L BarnhillDepartment of Translational Research Institut Curie, Paris Sciences and Lettres Research University; Faculty of Medicine, University of Paris Descartes, Paris, France.
Annie C LeeDivision of General Internal Medicine and Health Services Research, UCLA David Geffen School of Medicine, Los Angeles, California, USA.
Martiniano J FloresEdwards Lifesciences, Irvine, California, USA.
Kathleen F KerrDepartment of Biostatistics, University of Washington School of Public Health, Seattle, WA, USA.
Lisa M ReischDepartment of Biostatistics, University of Washington School of Public Health, Seattle, WA, USA.
Joann G ElmoreDivision of General Internal Medicine and Health Services Research, UCLA David Geffen School of Medicine, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-7311-6835

Funding

Accuracy in the Diagnosis of Melanoma & the Impact of Double ReadingR01CA151306 · NCI · UNIVERSITY OF WASHINGTON · PI ELMORE, JOANN G · 2011 to 2015
$4.1M
CALIFORNIA CENTER FOR POPULATION TRAINING PROGRAMT32HD007545 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HIRAM BELTRAN-SANCHEZ, Megan M Sweeney · 2001 to 2026
$4.1M
Reducing Errors in the Diagnosis of Melanoma and Melanocytic LesionsR01CA201376 · NCI · UNIVERSITY OF WASHINGTON · PI ELMORE, JOANN G, KERR, KATHLEEN F. · 2016 to 2020
$3.2M
Improving Melanoma Pathology Accuracy through Computer Vision Techniques - the IMPACT StudyR01CA200690 · NCI · UNIVERSITY OF WASHINGTON · PI ELMORE, JOANN G, SHAPIRO, LINDA · 2016 to 2020
$1.9M
NCI NIH HHS R01 CA151306NCI NIH HHS R01CA151306NCI NIH HHS R01 CA200690NCI NIH HHS R01CA200690NCI NIH HHS R01 CA201376NCI NIH HHS R01CA201376NICHD NIH HHS T32 HD007545
6 · The paper itself

Abstract

backgroundMelanocytic tumors are often challenging and constitute almost one in four skin biopsies. Immunohistochemical (IHC) studies may assist diagnosis; however, indications for their use are not standardized.

methodsA test set of 240 skin biopsies of melanocytic tumors was examined by 187 pathologists from 10 US states, interpreting 48 cases in Phase I and either 36 or 48 cases in Phase II. Participant and diagnosis characteristics were compared between those who reported they would have ordered, or who would have not ordered IHC on individual cases. Intraobserver analysis examined consistency in the intent to order when pathologists interpreted the same cases on two occasions.

resultsOf 187 participants interpreting 48 cases each, 21 (11%) did not request IHC tests for any case, 85 (45%) requested testing for 1 to 6 cases, and 81 (43%) requested testing for ≥6 cases. Of 240 cases, 229 had at least one participant requesting testing. Only 2 out of 240 cases had more than 50% of participants requesting testing. Increased utilization of testing was associated with younger age of pathologist, board-certification in dermatopathology, low confidence in diagnosis, and lesions in intermediate MPATH-Dx classes 2 to 4. The median intraobserver concordance for requesting tests among 72 participants interpreting the same 48 cases in Phases I and II was 81% (IQR 73%-90%) and the median Kappa statistic was 0.20 (IQR 0.00, 0.39).

conclusionSubstantial variability exists among pathologists in utilizing IHC.

Indexed as

BiomarkersBiopsyFemaleHistological TechniquesHumansImmunohistochemistryMaleMelanocytesMelanomaMiddle AgedObserver VariationPathologistsPathology, ClinicalSkinSkin NeoplasmsSurveys and QuestionnairesBiomarkershistopathological diagnosisimmunohistochemical markersmelanoma

Identifiers

PMID32383301
PMCPMC8845493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.