Evidence map›Paper›PMID 32383274›Full record

GuidelineJournal of clinical periodontology2020

Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline.

Mariano Sanz, David Herrera, Moritz Kebschull, Iain Chapple, Søren Jepsen, Tord Beglundh, Anton Sculean, Maurizio S Tonetti, EFP Workshop Participants and Methodological Consultants

Erratum issued 19 registry-linked trialsOpen access · bronzeAbstract readPractice Guideline
In one paragraph

Guideline in Journal of clinical periodontology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 19 registered trials, which are not on this map. Cited by 974 papers, 27 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
974citing papers in PubMed, 27 pooled it
106.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04871373 nacompletednot on this map

The Effect of Motivational Interviewing on Oral Hygiene Behavior in Patients With Fixed Orthodontic Appliances: A Randomised Clinical Trial

TypeinterventionalSponsorUniversidad IberoamericanaRan2017 to 2018Enrolled45ConditionsMotivational Interviewing, Oral Hygiene, Orthodontic Appliance ComplicationArmsMotivational interviewing, Oral Hygiene Instructions
NCT05137392 nacompletednot on this mapstarted 2022, after this paper: background citation

Impact of Intensive Oral Hygiene Regimen Based on Individualized Messages and an Intelligent Power-driven Toothbrush on Non-surgical Treatment of Stage II and III Periodontitis: A Randomized, Standard of Care-controlled Trial

TypeinterventionalSponsorShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong UniversityRan2022 to 2023Enrolled100ConditionsPeriodontitisArmsoral hygiene instruction
NCT05360511 early_phase1completednot on this mapstarted 2022, after this paper: background citation

Erythropoietin Gel as an Adjunct to Xenograft in the Surgical Management of Intrabony Periodontal Defects. A Randomized Controlled Clinical Study

TypeinterventionalSponsorAin Shams UniversityRan2022 to 2023Enrolled26ConditionsPeriodontal Bone LossArmsparticulate xenograft + erythropoietin gel., particulate xenograft
NCT05447026 nacompletednot on this map

The Adjunctive Use of Antimicrobial Photodynamic Therapy, Light-emitting-diode Photobiomodulation, and Ozone Therapy in Regenerative Treatment of Stage III Grade C Periodontitis

TypeinterventionalSponsorGazi UniversityRan2018 to 2022Enrolled48ConditionsPeriodontitis, Lasers, Ozone, Wound HealingArmsControl group, Antimicrobial photodynamic therapy (aPDT) group, LED photobiomodulation group, Topical ozone group
NCT06684288 nacompletednot on this mapstarted 2021, after this paper: background citation

Efficacy of Access Flap Surgery on Subgingival Periodontopathogen Levels in Periodontitis Patients: A Split-Mouth Randomized Clinical Trial

TypeinterventionalSponsorTrakya UniversityRan2021 to 2022Enrolled20ConditionsPeriodontitisArmsAccess flap surgery
NCT06719674 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Impact of Diode Laser as an Adjunct to Professional Mechanical Plaque Removal (PMPR) in Patients With Periodontitis: A Randomized Clinical Trial

TypeinterventionalSponsorUniversity of SulaimaniRan2025 to 2026Enrolled40ConditionsPeriodontitis, Pocket, PeriodontalArmsProfessional mechanical plaque removal and Laser, Professional mechanical plaque removal
NCT06740123 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Clinical, Radiological, and Biochemical Evaluation of Adjunctive Hydrogel Application in the Non-Surgical Treatment of Peri-implantitis and Periodontitis

TypeinterventionalSponsorKutahya Health Sciences UniversityRan2024 to 2026Enrolled30ConditionsPeriodontal Disease Stage 2, Peri-Implantitis and Peri-implant Mucositis, Periodontal RegenerationArmsNonsurgical periodontal treatment and application of H42® hydrogel to the peri-implant pocket, Nonsurgical periodontal treatment of periodontal pocket, Non-surgical periodontal treatment and application of H42® hydrogel to the periodontal pocket, Nonsurgical periodontal treatment of peri-implant pocket
NCT06753682 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effect of the Healthy Plant-based Dietary Pattern as an Adjunct to Non-surgical Periodontal Treatment in Periodontitis: A Randomized Controlled Clinical Trial

TypeinterventionalSponsorThe University of Hong KongRan2024 to 2026Enrolled78ConditionsPeriodontal Diseases, Periodontitis, DietArmsHealthy Plant Based Diet
NCT06894667 phase4active not recruitingnot on this mapstarted 2024, after this paper: background citation

The Effect of an Antioxidant Gel Compared to Chlorhexidine Gel During the Soft Tissue Healing Process Follow Scaling and Root Planing: A Randomized Controlled Clinical Trial

TypeinterventionalSponsorKuwait UniversityRan2024 to 2025Enrolled40ConditionsPeriodontal DiseasesArmsAntioxidant gel, Antimicrobial gel
NCT06897085 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of a Gel Containing Polynucleotides and Hyaluronic Acid in the Treatment of Periodontal Supraosseous Defects with the Single Flap Approach: a Randomized Controlled Trial

TypeinterventionalSponsorAzienda Unità Sanitaria Locale (A.U.S.L.) Ferrara, ItalyRan2025 to 2026Enrolled70ConditionsPeriodontitis, Gingival Recession, Localized, Aesthetic Perception, Aesthetic OutcomesArmsviscoelastic gel containing polynucleotides and hyaluronic acid, No intervention
NCT07077122 narecruitingnot on this mapstarted 2025, after this paper: background citation

Evaluation of the Systemic Burden of Non-surgical Periodontal Therapy: A Randomized Clinical Trial on Five Different Treatment Protocols

TypeinterventionalSponsorNational and Kapodistrian University of AthensRan2025 to 2027Enrolled75ConditionsPeriodontitisArmsScaling and Root Planing, antibiotic prophylaxis, 810nm Diode Laser, Air Polishing
NCT07293962 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Liquid S-Platelet Rich Fibrin as a Potential Adjunct in Conservative Closed Periodontal Debridement for Periodontitis Stages II-IV: A Randomized, Split-mouth, 3-month Clinical Trial

TypeinterventionalSponsorMahsa UniversityRan2024 to 2026Enrolled14ConditionsPeriodontitis Stage II, Periodontitis Stage III, Periodontitis (Stage 3), PeriodontitisArmsNormal saline irrigation, Platelet rich fibrin
NCT07523841 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

The Efficacy of Non-surgical Periodontal Therapy in Combination With Aspirin and Omega-3 Fatty Acids.

TypeinterventionalSponsorHanoi Medical UniversityRan2023 to 2027Enrolled120ConditionsPeriodontitis, Periodontitis (Stage 3)ArmsScaling and Root Planing (SRP), Omega-3 Fatty Acids, Low-dose aspirin
NCT07549347 narecruitingnot on this mapstarted 2026, after this paper: background citation

Optimal Oral Care Regimen With or Without Professional Mechanical Plaque Removal in Managing Gingivitis (Gingival Inflammation): A Non-inferiority Randomized Controlled Trial

TypeinterventionalSponsorShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong UniversityRan2026 to 2027Enrolled92ConditionsGingivitis, PeriodontitisArmsOptimal oral care regimen, Periodontal Treatment, Sham Periodontal Treatment
NCT07589959 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Polynucleotides and Hyaluronic Acid vs Enamel Matrix Derivative Proteins in the Treatment of Intrabony Defects: A Randomized Controlled Clinical Trial

TypeinterventionalSponsorShashi DadlaniRan2026 to 2031Enrolled40ConditionsPeriodontal Bone Loss, Periodontal Defect, Periodontitis Stage III, Periodontitis Stage IVArmsRegenerative periodontal surgery using Regenfast® (hyaluronic acid + polynucleotides) with Bio-Oss® graft, Regenerative periodontal surgery using Emdogain® (enamel matrix derivative) with Bio-Oss® graft
NCT07593742 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Smoking Cessation Programme in Telerehabilitation Assisted by Telemonitoring With Non-Invasive Wearable Devices for the Improvement of Oral Health, General Health and Quality of Life

TypeinterventionalSponsorUniversity of SalernoRan2026 to 2027Enrolled102ConditionsSmoking ( Cigarette), Smoking (Tobacco) Addiction, Smoking Behaviors, Smoking CessationArmsTelemedicine-Based Smoking Cessation Program, Conventional Smoking Cessation Behavioral Program
NCT07604636 nacompletednot on this mapstarted 2024, after this paper: background citation

Clinical and Microbiological Effects of Adjunctive Ozone Application During Repeated Scaling and Root Planing for Residual Periodontal Pockets in Periodontal Maintenance Patients: A 6-Month Randomized Controlled Clinical Trial

TypeinterventionalSponsorAtaturk UniversityRan2024 to 2025Enrolled26ConditionsPeriodontitis, Residual Periodontal Pocket, Periodontal Pocket, Stage III PeriodontitisArmsScaling and Root Planing, Gaseous Ozone Application
NCT07609888 nacompletednot on this mapstarted 2023, after this paper: background citation

Efficacy of Antimicrobial Photodynamic Therapy as an Adjunct to Non-Surgical Periodontal Therapy in Stage II Periodontitis: A Randomized Split-Mouth Study

TypeinterventionalSponsorGulf Medical UniversityRan2023 to 2024Enrolled30ConditionsPeriodontitis, Chronic Periodontitis (Disorder)ArmsNon-Surgical Periodontal Therapy (NSPT), Antimicrobial Photodynamic Therapy (aPDT) with Indocyanine Green and 810 nm Diode Laser
NCT07634341 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Clinical and Radiographic Evaluation of Doxycycline and Atorvastatin Loaded Chitosan Nanoparticles as an Adjunctive to Scaling and Root Planning in the Management of Chronic Periodontitis: A Randomized Controlled Clinical Trial.

TypeinterventionalSponsorFayoum UniversityRan2026 to 2027Enrolled80ConditionsChronic PeriodontitisArmsDoxycycline and Atorvastatin loaded Chitosan nanoparticles local drug
3 · Its place in the literature

Who cites it

974 citing papers in PubMed, 27 syntheses or guidelines pooled it, 1,619 citations in OpenAlex.

  1. Pooled it
  2. Efficacy of adjunct Nd-YAG laser (1064 nm) to non-surgical periodontal therapy: a systematic review and meta-analysis of randomized controlled trials.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
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  4. Guideline
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914 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 8 countries.

Mariano SanzETEP (Etiology and Therapy of Periodontal and Peri-implant Diseases) Research Group, University Complutense of Madrid, Madrid, Spain.ORCID 0000-0002-6293-5755
David HerreraETEP (Etiology and Therapy of Periodontal and Peri-implant Diseases) Research Group, University Complutense of Madrid, Madrid, Spain.ORCID 0000-0002-5554-2777
Moritz KebschullPeriodontal Research Group, Institute of Clinical Sciences, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, UK.ORCID 0000-0003-1863-0679
Iain ChapplePeriodontal Research Group, Institute of Clinical Sciences, College of Medical and Dental Sciences, The University of Birmingham, Birmingham, UK.ORCID 0000-0003-2697-7082
Søren JepsenDepartment of Periodontology, Operative and Preventive Dentistry, University Hospital Bonn, Bonn, Germany.ORCID 0000-0002-4160-5837
Tord BeglundhDepartment of Periodontology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.ORCID 0000-0001-5864-6398
Anton SculeanDepartment of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.ORCID 0000-0003-2836-5477
Maurizio S TonettiDivision of Periodontology and Implant Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong, Hong Kong.ORCID 0000-0002-2743-0137
EFP Workshop Participants and Methodological Consultants
Birmingham Community Healthcare NHS Trust · GBUniversidad Complutense de Madrid · ESShanghai Jiao Tong University · CNUniversity Hospital Bonn · DEUniversity of Bern · CHUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe recently introduced 2017 World Workshop on the classification of periodontitis, incorporating stages and grades of disease, aims to link disease classification with approaches to prevention and treatment, as it describes not only disease severity and extent but also the degree of complexity and an individual's risk. There is, therefore, a need for evidence-based clinical guidelines providing recommendations to treat periodontitis.

aimThe objective of the current project was to develop a S3 Level Clinical Practice Guideline (CPG) for the treatment of Stage I-III periodontitis. MATERIAL AND

methodsThis S3 CPG was developed under the auspices of the European Federation of Periodontology (EFP), following the methodological guidance of the Association of Scientific Medical Societies in Germany and the Grading of Recommendations Assessment, Development and Evaluation (GRADE). The rigorous and transparent process included synthesis of relevant research in 15 specifically commissioned systematic reviews, evaluation of the quality and strength of evidence, the formulation of specific recommendations and consensus, on those recommendations, by leading experts and a broad base of stakeholders.

resultsThe S3 CPG approaches the treatment of periodontitis (stages I, II and III) using a pre-established stepwise approach to therapy that, depending on the disease stage, should be incremental, each including different interventions. Consensus was achieved on recommendations covering different interventions, aimed at (a) behavioural changes, supragingival biofilm, gingival inflammation and risk factor control; (b) supra- and sub-gingival instrumentation, with and without adjunctive therapies; (c) different types of periodontal surgical interventions; and (d) the necessary supportive periodontal care to extend benefits over time.

conclusionThis S3 guideline informs clinical practice, health systems, policymakers and, indirectly, the public on the available and most effective modalities to treat periodontitis and to maintain a healthy dentition for a lifetime, according to the available evidence at the time of publication.

Indexed as

GingivitisPeriodontitisGermanyHealth BehaviorHumansPeriodonticsclinical guidelinegradehealth policyoral healthperiodontal therapyperiodontitisstage

Identifiers

PMID32383274
PMCPMC7891343
OpenAlexW3021393259

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

and 13 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.