Evidence map›Paper›PMID 32383076›Full record

ArticleMolecular imaging and biology2020

The Effects of an Albumin Binding Moiety on the Targeting and Pharmacokinetics of an Integrin α

Sven H Hausner, Nadine Bauer, Ryan A Davis, Tanushree Ganguly, Sarah Y C Tang, Julie L Sutcliffe

Open access · greenAbstract read
In one paragraph

Article in Molecular imaging and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Preclinical Evaluation of an Integrin αBioconjugate chemistry · 2025
    Article
  2. Article
  3. Evaluation of [Molecular imaging and biology · 2025
    Article
  4. Article
  5. Preclinical Evaluation ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  6. Article
  7. Therapeutic Efficacy ofPharmaceuticals (Basel, Switzerland) · 2022
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sven H HausnerDivision of Hematology/Oncology, Department of Internal Medicine, University of California Davis, Sacramento, CA, USA.
Nadine BauerDivision of Hematology/Oncology, Department of Internal Medicine, University of California Davis, Sacramento, CA, USA.
Ryan A DavisDepartment of Biomedical Engineering, University of California Davis, Davis, CA, USA.
Tanushree GangulyDivision of Hematology/Oncology, Department of Internal Medicine, University of California Davis, Sacramento, CA, USA.
Sarah Y C TangDivision of Hematology/Oncology, Department of Internal Medicine, University of California Davis, Sacramento, CA, USA.
Julie L SutcliffeDivision of Hematology/Oncology, Department of Internal Medicine, University of California Davis, Sacramento, CA, USA. jlsutcliffe@ucdavis.edu.
University of California, Davis · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
avb6-directed molecular imaging and therapyR01CA199725 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SUTCLIFFE, JULIE L · 2016 to 2019
$1.9M
Molecular Imaging Probe DevelopmentR50CA211556 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAUSNER, SVEN H · 2017 to 2021
$1.0M
First in human study with 18F-avb6-targeting peptideR01CA211554 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SUTCLIFFE, JULIE L · 2017 to 2019
$777k
NCI NIH HHS P30 CA093373NCI NIH HHS R01 CA199725NCI NIH HHS R01 CA211554NCI NIH HHS R50 CA211556
6 · The paper itself

Abstract

purposeThe α PROCEDURES: The peptides NOTA-α

resultsThe peptides were radiolabeled in 23.0 ± 5.7 % and 22.1 ± 4.4 % decay-corrected radiochemical yield, respectively, for [

conclusionBoth compounds were prepared using standard chemistries; affinity and selectivity for integrin α

Indexed as

AlbuminsAluminum CompoundsAnimalsAntigens, NeoplasmCell Line, TumorFemaleFluoridesFluorine RadioisotopesIntegrinsMice, NudePeptidesPositron Emission Tomography Computed TomographyProtein BindingTissue DistributionAlbuminsAluminum Compoundsaluminum fluorideAntigens, NeoplasmFluoridesFluorine-18Fluorine Radioisotopesintegrin alphavbeta6IntegrinsPeptidesAlbuminAlbumin binding moietyAluminum [18F]fluorideBlood circulationIntegrin αvβ6PeptidePET imaging

Identifiers

PMID32383076
PMCPMC7647958
OpenAlexW3023469949

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.