Evidence map›Paper›PMID 32383065›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2020

Teriparatide improves microarchitectural characteristics of peri-implant bone in orchiectomized rats.

P H S Gomes-Ferreira, D de Oliveira, P B Frigério, F R de Souza Batista, K Grandfield, R Okamoto

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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

P H S Gomes-FerreiraDepartment of Surgery and Integrated Clinic, Araçatuba Dental School, São Paulo State University, Rua José Bonifácio, 1193, Vila Mendonça, Aracatuba, SP, 16015-050, Brazil. pedroferreirabmf@gmail.com.ORCID http://orcid.org/0000-0002-8936-3662
D de OliveiraDepartment of Basic Sciences, Araçatuba Dental School, São Paulo State University, Araçatuba, SP, Brazil.
P B FrigérioDepartment of Basic Sciences, Araçatuba Dental School, São Paulo State University, Araçatuba, SP, Brazil.
F R de Souza BatistaDepartment of Surgery and Integrated Clinic, Araçatuba Dental School, São Paulo State University, Rua José Bonifácio, 1193, Vila Mendonça, Aracatuba, SP, 16015-050, Brazil.
K GrandfieldDepartment of Materials Science and Engineering, McMaster University, Hamilton, ON, Canada.
R OkamotoDepartment of Basic Sciences, Araçatuba Dental School, São Paulo State University, Araçatuba, SP, Brazil.
Universidade Estadual Paulista (Unesp) · BRCentro Universitario Toledo · BRMcMaster University · CA

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/04649-7 and 2015/14688-0
6 · The paper itself

Abstract

This study evaluated the peri-implant bone repair in orchiectomized rats receiving intermittently PTH 1-34. The treatment returned the bone quality and quantity of the animals to normal in the computerized microtomography, laser confocal microscopy, and histological analysis. The PTH 1-34 promoted marked bone formation with increased volume, improved quality, and greater bone turnover.

introductionOsteoporosis can be a problem in implant osseointegration. So this study aimed to evaluate the quantity and quality of peri-implant bone repair in orchiectomized Wistar rats receiving intermittently administered PTH 1-34.

methodsAnimals (n = 24) were divided into 3 groups: healthy control (SHAM), orchiectomized (ORQ), and orchiectomized and treated with 0.5 μg/kg/day PTH 1-34 (TERI), and each received an implant in the right and left tibial metaphysis, which was allowed to repair for 60 days. The resultant bone formation was evaluated through computerized microtomography (micro-CT) to compare the percent bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular number and separation (Tb.N, Tb.Sp), and bone implant contact (BIC) through the intersection surface (i.S) between groups. Laser confocal microscopy was used to evaluate fluorochrome areas for mineral apposition rate (MAR) and neoformed bone area (NBA). In addition, histological evaluation of calcified tissues with Stevenel blue and alizarin red staining was performed.

resultsTreatment with PTH 1-34 returned the bone quality and quantity of the osteoporotic animal to normal, as the TERI group presented statistically significant higher values for BV/TV, Tb.Th, and BIC parameters compared with ORQ (p < 0.05), but when compared with SHAM (p > 0.05), no statistical difference was noted. In addition, in the bone turnover analysis (MAR, NBA) for TERI, the highest results are presented, followed by SHAM, and then ORQ (TERI × ORQ: p < 0.05).

conclusionsIntermittent treatment with PTH 1-34 on orchiectomized animals promoted marked bone formation with increased volume, improved quality, and greater bone turnover in the peri-implant space, returning the bone quality and quantity to the present standard in healthy animals.

Indexed as

OsteoporosisTeriparatideAnimalsBone and BonesBone DensityFemaleHumansOsseointegrationOvariectomyRatsRats, WistarX-Ray MicrotomographyTeriparatideBone histomorphometryBone QCTImplantsMicro-computed tomographyOsseointegrationOsteoporosisPTH

Identifiers

PMID32383065
OpenAlexW3022300238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.