Evidence map›Paper›PMID 32383041›Full record

ArticleAnnals of biomedical engineering2021

The Role of Feedback Control Design in Developing Anemia Management Protocols.

Yossi Chait, Michael J Germain, Christopher V Hollot, Joseph Horowitz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yossi ChaitMechanical and Industrial Engineering Department, University of Massachusetts, Amherst, MA, 01003, USA. ychait@umass.edu.ORCID http://orcid.org/0000-0002-6581-8124
Michael J GermainRenal and Transplant Associates of New England, PC, Springfield, MA, 01107, USA.
Christopher V HollotElectrical and Computer Engineering Department, University of Massachusetts, Amherst, MA, 01003, USA.
Joseph HorowitzMathematics and Statistics Department, University of Massachusetts, Amherst, MA, 01003, USA.
University of Massachusetts Amherst · USBaystate Medical Center · US

Funding

The Engineering of Individualized Anemia Management ProtocolsK25DK096006 · NIDDK · UNIVERSITY OF MASSACHUSETTS AMHERST · PI CHAIT, YOSSI · 2013 to 2016
$670k
NIDDK NIH HHS K25 DK096006NIH HHS DK096006
6 · The paper itself

Abstract

The optimal use of erythropoiesis stimulating agents to treat anemia of end-stage renal disease remains difficult due to reported associations with adverse events. A patient's hemoglobin response to these agents cannot be accurately described using population-level models due to many individual factors including chronic inflammation, red blood cell lifespan, and acute blood loss. As a consequence, it is generally understood that current one-size-fits-all anemia management protocols result in suboptimal outcomes. In this paper, we report on our collaboration with the medical community in designing anemia management protocols. In clinical implementation, these new dosing protocols have led to improved outcomes due to their use of control-relevant modelling, model parameter identification, and principles of feedback control. This is an example of medical professionals and control engineers working together to positively affect the performance of anemia management protocols in end-stage renal disease.

Indexed as

Feedback, PhysiologicalAnemiaClinical ProtocolsErythropoiesisHematinicsHemoglobinsHumansKidneyKidney Failure, ChronicModels, BiologicalHematinicsHemoglobinsAnemia managementBiomedical control systemsDrug dosing algorithmsErythropoiesis stimulating agents feedback algorithms

Identifiers

PMID32383041
PMCPMC7647949
OpenAlexW3021984637

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.