Evidence map›Paper›PMID 32382973›Full record

ArticleGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2020

Endoscopic three-categorical diagnosis of Helicobacter pylori infection using linked color imaging and deep learning: a single-center prospective study (with video).

Hirotaka Nakashima, Hiroshi Kawahira, Hiroshi Kawachi, Nobuhiro Sakaki

Open access · bronzeAbstract readClinical StudyVideo-Audio Media
PubMed Publisher
In one paragraph

Article in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Artificial intelligence in gastric cancer: a systematic review.Journal of cancer research and clinical oncology · 2020
    Pooled it
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. AI-powered three-categoryFrontiers in microbiology · 2025
    Article
  14. Review
  15. Article
  16. Endoscopic appearances of gastric mucosa in different endoscopic models according to H. pylori infection status.JGH open : an open access journal of gastroenterology and hepatology · 2024
    Review
  17. Article
  18. Applications of artificial intelligence in gastroscopy: a narrative review.The Journal of international medical research · 2024
    Review
  19. Clinical usefulness of linked color imaging in identifyingWorld journal of gastrointestinal endoscopy · 2023
    Article
  20. Diagnostic usefulness of deep learning methods forJGH open : an open access journal of gastroenterology and hepatology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Hirotaka NakashimaFoundation for Detection of Early Gastric Carcinoma, 2-6-12 Nihombashikayabacho Chuo Ward, Tokyo, 103-0025, Japan. nakashima@soiken.or.jp.ORCID http://orcid.org/0000-0002-2386-1933
Hiroshi KawahiraMedical Simulation Center, Jichi Medical University, Tochigi, Japan.
Hiroshi KawachiDepartment of Pathology, Cancer Institute Hospital Japanese Foundation for Cancer Research, Tokyo, Japan.
Nobuhiro SakakiFoundation for Detection of Early Gastric Carcinoma, 2-6-12 Nihombashikayabacho Chuo Ward, Tokyo, 103-0025, Japan.
Japanese Foundation For Cancer Research · JPJichi Medical University · JPThe Nakamura Hajime Eastern Institute · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHelicobacter pylori (H. pylori) eradication is required to reduce incidence related to gastric cancer. Recently, it was found that even after the successful eradication of H. pylori, an increased, i.e., moderate, risk of gastric cancer persists in patients with advanced mucosal atrophy and/or intestinal metaplasia. This study aimed to develop a computer-aided diagnosis (CAD) system to classify the status of H. pylori infection of patients into three categories: uninfected (with no history of H. pylori infection), currently infected, and post-eradication.

methodsThe CAD system was based on linked color imaging (LCI) combined with deep learning (DL). First, a validation dataset was formed for the CAD systems by recording endoscopic movies of 120 subjects. Next, a training dataset of 395 subjects was prepared to enable DL. All endoscopic examinations were recorded using both LCI and white-light imaging (WLI). These endoscopic data were used to develop two different CAD systems, one for LCI (LCI-CAD) and one for WLI (WLI-CAD) images.

resultsThe diagnostic accuracy of the LCI-CAD system was 84.2% for uninfected, 82.5% for currently infected, and 79.2% for post-eradication status. Comparisons revealed superior accuracy of diagnoses based on LCI-CAD data relative based on WLI-CAD for uninfected, currently infected, and post-eradication cases. Furthermore, the LCI-CAD system demonstrated comparable diagnostic accuracy to that of experienced endoscopists with the validation data set of LCI.

conclusionsThe results of this study suggest the feasibility of an innovative gastric cancer screening program to determine cancer risk in individual subjects based on LCI-CAD.

Indexed as

Deep LearningAgedArea Under CurveAtrophyColorDiagnosis, Computer-AssistedEndoscopy, Digestive SystemFeasibility StudiesFemaleGastric MucosaHelicobacter InfectionsHelicobacter pyloriHumansImage EnhancementMaleMiddle AgedDeep convolutional neural networkHelicobacter pylori infectionImage enhanced endoscopyRisk of gastric cancer

Identifiers

PMID32382973
OpenAlexW3022742353

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.