Evidence map›Paper›PMID 32382935›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2020

Early and sustained improvement in fatigue-related quality of life following red blood cell transfusion in outpatients.

Roberta Bruhn, Matthew S Karafin, Joan F Hilton, Zhanna Kaidarova, Bryan R Spencer, Lirong Qu, Edward L Snyder, Rebecca Olin, Edward L Murphy, Elizabeth St Lezin and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Outpatient transfusions for myelodysplastic syndromes.Hematology. American Society of Hematology. Education Program · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Roberta BruhnVitalant Research Institute, San Francisco, CA, USA.
Matthew S KarafinVersiti, Milwaukee, WI, USA.
Joan F HiltonUniversity of California San Francisco, San Francisco, CA, USA.
Zhanna KaidarovaVitalant Research Institute, San Francisco, CA, USA.
Bryan R SpencerAmerican Red Cross, Scientific Affairs, Dedham, MA, USA.
Lirong QuInstitute for Transfusion Medicine, Pittsburgh, PA, USA.
Edward L SnyderYale Medical School, New Haven, CT, USA.
Rebecca OlinUniversity of California San Francisco, San Francisco, CA, USA.
Edward L MurphyVitalant Research Institute, San Francisco, CA, USA.
Elizabeth St LezinUniversity of California San Francisco, San Francisco, CA, USA. Elizabeth.st.lezin@va.gov.ORCID http://orcid.org/0000-0001-6191-3418
NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS)-III Program
University of California, San Francisco · USAmerican Red Cross · USPacific Research Institute · USYale University · US

Funding

NHLBI NIH HHS -00002INHLBI NIH HHS -00003INHLBI NIH HHS -00004INHLBI NIH HHS -00005INHLBI NIH HHS -00006INHLBI NIH HHS -00007INHLBI NIH HHS -00008INHLBI NIH HHS -00009INHLBI NIH HHS HHSN2682011-00001INHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100005IWHI NIH HHS HHSN268201100001C
6 · The paper itself

Abstract

purposeOutpatients with hematologic disease often receive red cell transfusion to treat anemia and fatigue. The effect of transfusion on fatigue-related quality of life and how well this effect is sustained has not been quantified. The study aim was to describe the early and sustained impact over 4 weeks of red cells on patient-reported fatigue in outpatients age ≥ 50 receiving transfusion as routine clinical care.

methodsFACIT-Fatigue scale scores were measured pre-transfusion and at visits targeting 3, 7, and 28 days post-transfusion. Group-based trajectory modeling of patient fatigue scores by study day was used to identify the number of distinct trajectories (Groups), then longitudinal mixed effects modeling of fatigue scores was used to estimate group-specific mean improvements early after transfusion and between days 3 and 28 post-transfusion.

resultsFour distinct fatigue score trajectory groups were identified and were found to be correlated with baseline fatigue scores (means 12, 26, 34, and 47 points). In the three groups with the lowest fatigue trajectories (indicating greater fatigue), improvements in fatigue early after transfusion achieved the established minimum clinically important difference (≥ 3 points, Group p = 0.0039). In all trajectory groups, mean fatigue levels did not change significantly between 3 and 28 days (± 1 point, Group p = 0.60).

conclusionPatient-reported fatigue varies widely among older adult outpatients with hematologic disorders. Nonetheless, trajectory modeling suggests that most anemic patients can expect a noticeable improvement in fatigue in the first few days after transfusion that generally is sustained up to 4 weeks.

Indexed as

AgedErythrocyte TransfusionFatigueFemaleHumansMaleMiddle AgedOutpatientsProspective StudiesQuality of LifeFatigueFatigue-related quality of lifePatient-reported outcomesRed blood cellsTransfusion practice

Identifiers

PMID32382935
PMCPMC7572478
OpenAlexW3021738122

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.