ArticleHeliyon2019
Hepatoprotective and antioxidant activity of hydroalcoholic extract of
Article in Heliyon, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
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- Genus Stachys-Phytochemistry, Traditional Medicinal Uses, and Future Perspectives.Molecules (Basel, Switzerland) · 2024Review
- The protective effect of DMI on hippocampus EEG, behavioral and biochemical parameters in hypoxia-induced seizure on neonatal period.PloS one · 2024Article
- Article
- Review
- Protective effects of hydroalcoholic extract ofResearch in pharmaceutical sciences · 2021Article
- Effect of ethanolic extract ofResearch in pharmaceutical sciences · 2021Article
- Chitosan from Crabs (Pathophysiology : the official journal of the International Society for Pathophysiology · 2021Article
- The potential effect of phytochemicals and herbal plant remedies for treating drug-induced hepatotoxicity: a review.Molecular biology reports · 2021Review
- Liposome Extract of Stachys pilifera Benth Effectively Improved Liver Damage due to Bile Duct Ligation Rats.Oxidative medicine and cellular longevity · 2021Article
- Effects ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Protective Effect of Hydroalcoholic Extract ofJournal of toxicology · 2021Article
- Nephroprotective Effects ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Antioxidant and Anti-Inflammatory Effects ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Protective Effects of Hydroalcoholic Extract ofJournal of toxicology · 2021Article
- The Effect of the Hydroalcoholic Extract of Watercress on the Levels of Protein Carbonyl, Inflammatory Markers, and Vitamin E in Chronic Hemodialysis Patients.Biochemistry research international · 2021Article
- Nephroprotective property of3 Biotech · 2020Article
- GenusMedicines (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcetaminophen (APAP) at high doses causes adverse side effects such as hepatotoxicity. The aim of the current study was to investigate the hepatoprotective and antioxidant effects of hydroalcoholic extract of
methodsAdult male Wistar rats were allocated into four groups: control (C), APAP (2 g/kg), APAP + SP (500 mg/kg), and APAP + Silymarin (SM, 100 mg/kg) as positive control group. On the seventh day, the rats were sacrificed after taking blood samples. Then levels of biochemical parameters, oxidative stress markers and activity of antioxidant enzymes were measured.
resultsIn the APAP group, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzymes activity was significantly increased and the level of protein carbonyl (PCO) was insignificantly increased as compared to control group. In addition, the activity of glutathione peroxidase (GPX) and total thiol in the APAP group was significantly decreased compared to the normal rats.
conclusionHydroalcoholic extract of SP diminishes hepatotoxicity induced by APAP by reducing the amount of liver function indicators (AST and ALT). Furthermore, the hydroalcoholic extract of SP is capable of reducing oxidative stress through inhibiting protein oxidation as well as boosting the activity of GPX enzyme. In this respect, the hepatoprotective impact induced by the SP extract may possibly be attributable to its reactive oxygen species scavenging and antioxidant properties.
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