ArticleBioMed research international2020
Bioinformatics Analysis of the Molecular Mechanism of Late-Stage Heterotopic Ossification.
Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Transcriptomic insights into the anti-apoptotic effect of Tuina in rabbit model of intervertebral disc degeneration.Journal of orthopaedic surgery and research · 2025Article
- The impact of aging on achilles tendon ossification in mice.BMC musculoskeletal disorders · 2025Article
- Comparative proteomic analysis identifies differentially expressed proteins and reveals potential mechanisms of traumatic heterotopic ossification progression.Journal of orthopaedic translation · 2022Article
- Screening and identification of osteoarthritis related differential genes and construction of a risk prognosis model based on bioinformatics analysis.Annals of translational medicine · 2022Article
- Identification of the Biomarkers and Pathological Process of Heterotopic Ossification: Weighted Gene Co-Expression Network Analysis.Frontiers in endocrinology · 2020Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHeterotopic ossification (HO) is a common disease happened in soft tissues after injury. The present study utilized the bioinformatics method to analyze the HO samples in a mouse burn/tenotomy-induced HO model to identify the possible key points and treatment targets.
methodsThe transcriptome profiles of GSE126118 were obtained from the Gene Expression Omnibus (GEO) database. The study was based on a mouse burn/tenotomy-induced HO model, and 2 tenotomy samples and 3 uninjured contralateral hindlimb tendon samples were collected at 3 weeks after injury for further analysis. The transcripts per million approach was performed for background correction and normalization; then, the differentially expressed genes (DEGs) were detected using the limma R package with the settings
resultsA total of 74 DEGs were upregulated, and 159 DEGs were downregulated between the tenotomy and uninjured tendon group. Pathway and process enrichment analyses demonstrated that the upregulated DEGs were mainly associated with terms related to ECM remodeling, ossification, angiogenesis, inflammation, etc., and the downregulated DEGs were mainly associated with oxidative phosphorylation, metabolic process, etc.
conclusionThe results of GO, KEGG, and PPI network analyses suggested that the ECM remodeling, ossification, angiogenesis, and inflammation processes were markedly upregulated in the tenotomy site. And the oxidative phosphorylation and metabolic processes were markedly downregulated. These findings provide valuable clues for highlighting the characteristics of late-stage HO and investigating possible treatments.
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