Evidence map›Paper›PMID 32382537›Full record

Trial reportBioMed research international2020

Comparison of the Efficacy of Three Loading Doses of Intravitreal Injection of Conbercept with Injection Combined with PDT for the Treatment of PCV.

Fengjiao Li, Aihua Ma, Bojun Zhao

Erratum issuedOpen access · hybridAbstract readClinical TrialComparative Study
In one paragraph

Trial report in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Fengjiao LiDepartment of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
Aihua MaDepartment of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.ORCID https://orcid.org/0000-0001-5673-9742
Bojun ZhaoDepartment of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.ORCID https://orcid.org/0000-0002-2113-7538
Shandong University · CNShandong Provincial Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the efficacy between initial 3-monthly intravitreal conbercept monotherapy and combination intravitreal conbercept with photodynamic therapy (PDT) for polypoidal choroidal vasculopathy (PCV).

methodsThis is a retrospective, comparative study which involved 65 PCV eyes of 65 patients. According to the therapeutic regimen, the PCV patients were divided into two groups: 32 eyes with naive PCV received a PDT after the first intravitreal injection of conbercept (IVC) followed by pro re nata (prn) retreatment (combination group), and 33 eyes with naïve PCV received 3-monthly IVC monotherapy followed by prn regimen (IVC monotherapy group). All patients completed at least 6 months of monthly follow-up.

resultsAt month 6, best-corrected visual acuity (BCVA) improved significantly (

conclusionConbercept monotherapy significantly improved visual acuity and effectively regressed polyps during 6-month follow-up time in the treatment of PCV.

Indexed as

PhotochemotherapyAgedChoroid DiseasesFemaleHumansIntravitreal InjectionsMaleMiddle AgedPolypsRecombinant Fusion ProteinsRetrospective StudiesVisual AcuityKH902 fusion proteinRecombinant Fusion Proteins

Identifiers

PMID32382537
PMCPMC7196131
OpenAlexW3018432080

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.