Evidence map›Paper›PMID 32382289›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2020

Tai Chi Improves Coronary Heart Disease Risk by Inactivating MAPK/ERK Pathway through Serum miR-126.

Guangwei Zhang, Shuli Wang, Yan Gu, Ling Song, Shui Yu, Xiaoxing Feng

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 4 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
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  4. Pooled it
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Guangwei Zhang *Department of Cardiovascular, The First Hospital of Jilin University, Changchun 130021, China.
Shuli Wang *Department of Cardiovascular, The First Hospital of Jilin University, Changchun 130021, China.
Yan GuDepartment of Cardiovascular, The First Hospital of Jilin University, Changchun 130021, China.
Ling SongDepartment of Cardiovascular, The First Hospital of Jilin University, Changchun 130021, China.
Shui YuDepartment of Cardiovascular, The First Hospital of Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0003-3729-3559
Xiaoxing FengDepartment of Cardiovascular, The First Hospital of Jilin University, Changchun 130021, China.ORCID https://orcid.org/0000-0002-8094-7215
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTai Chi is effective in preventing heart disease (CHD) risk, but the molecular mechanism remains unclear. Mitogen-activated protein kinase (MAPK) signaling plays a critical role in the pathogenesis of CHD and can be activated by miR-126. Tai Chi may exert its protective function through the miR-126-modulated MAPK pathway.

methodsThe CHD patients after PCI were randomized into the CG group (CG) (n = 19, normal care) and Tai Chi group (TG) (Tai Chi intervention, n = 17). Epicardial adipose tissue volume (EATV) (one main adverse cardiovascular event of CHD), HR (heart rate), QoL (quality of life) scores, and balance performance were measured in the two groups. The body fat content, abdominal subcutaneous fat, and visceral fat were measured to reflect the improvement of adipose tissue dysfunction. The levels of miR-126 and MAPK-associated molecules were measured in peripheral blood leukocytes. Meanwhile, the effects of miR-126 silence and mimic on MAPK-associated molecules were also explored in cardiac cell H9C2.

resultsAfter the 3-month intervention, Tai Chi reduced EATV and HR and increased QoL scores and balance performance, respectively (

conclusionsTai Chi improved CHD risk by inactivating the MAPK/ERK pathway via serum miR-126.

Identifiers

PMID32382289
PMCPMC7199556
OpenAlexW3018365695

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.