ReviewEvidence-based complementary and alternative medicine : eCAM2020
Plant Extracts for Sleep Disturbances: A Systematic Review.
Review in Evidence-based complementary and alternative medicine : eCAM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Efficacy and Tolerability of a Chemically CharacterizedNutrients · 2025Trial
- The efficacy of lavender oil on fatigue and sleep quality in patients with hematological malignancy receiving chemotherapy: a single-blind randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Effect of a nutraceutical combination on sleep quality among people with impaired sleep: a randomised, placebo-controlled trial.Scientific reports · 2024Trial
- Tilia Tomentosa promotes sleep, preserving sleep structure.Npj biological timing and sleep · 2026Article
- Targeting Gut Dysbiosis and Short-Chain Fatty Acid Deficiency in Chronic Eczema: A Case Report.Integrative medicine (Encinitas, Calif.) · 2026Article
- Longan flower water extract promotes sleep in mice via the serotonin-melatonin axis.Journal of the science of food and agriculture · 2026Article
- Effects ofJournal of microbiology and biotechnology · 2025Article
- Integrative sleep management: from molecular pathways to conventional and herbal treatments.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Oral supplement in healthy older adults to support physical fitness and mental wellbeing.Frontiers in nutrition · 2025Article
- Aromatherapy was used to explore the sedative and hypnotic effects ofFood science & nutrition · 2024Article
- Adulteration of Brain Health (Cognitive, Mood, and Sleep Enhancement) Food Supplements by the Addition of Pharmaceutical Drugs: A Comprehensive Review of Analytical Approaches and Trends.Foods (Basel, Switzerland) · 2024Review
- Self-Completion Questionnaire on Sleep Evaluation in Patients Undergoing Oxaliplatin Therapy: An Observational Study.Cancers · 2024Article
- Diet Composition and Objectively Assessed Sleep Quality: A Narrative Review.Journal of the Academy of Nutrition and Dietetics · 2022Review
- Inhalation AromatherapyFrontiers in pharmacology · 2022Review
- Study on the Sleep-Improvement Effects ofFoods (Basel, Switzerland) · 2021Article
- Sleeping without Prescription: Management of Sleep Disorders in Children with Autism with Non-Pharmacological Interventions and Over-the-Counter Treatments.Brain sciences · 2020Review
- Prevalence of Sleep Disturbance Potential-Associated Factors among Undergraduate Pharmacy Students in Saudi Arabia.Journal of pharmacy & bioallied sciencesArticle
- Anticancer Effects of Lavandula Angustifolia L. Essential Oil: Dose-Dependent Cytotoxicity in HNO210 Human Laryngeal Carcinoma Cells.The Journal of craniofacial surgeryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSleep complaints are common health issues in the general population. These conditions are associated with poorer physical and psychological activity, and they may have important social, economic, and personal consequences. In the last years, several food supplements with different plant extracts have been developed and are currently taken for improving sleep.
methodsWe searched the PubMed database up to 05/03/2020 based on data from randomized, double-blind, placebo-controlled trials, noncontrolled trials, and cohort studies conducted in children and adult subjects. The search words used contained the following terms: oral food supplement and sleep disorders and the like. The most studied compounds were further analyzed with a second search using the following terms: name of the compound and sleep disorders. We selected 7 emerging compounds and 38 relevant reports.
resultsAlthough nutraceutical natural products have been used for sleep empirically, there is a scarcity of evidence on the efficacy of each product in clinical studies. Valerian and lavender were the most frequently studied plant extracts, and their use has been associated (with conflicting results) with anxiolytic effects and improvements in quality and duration of sleep.
conclusionsSleep aids based on plant extracts are generally safe and well tolerated by the population. More high-quality research is needed to confirm the effectiveness of food supplements containing plant extracts in sleep complaints; in particular, it would be interesting to evaluate the association between plant extracts and sleep hygiene guidelines and to identify the optimal products to be used in a specific symptom of sleep complaint, giving more appropriate tools to the medical doctor.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.