Evidence map›Paper›PMID 32382005›Full record

ArticleCell death & disease2020

LGR5

Ting-Han Chang, Rabie M Shanti, Yanfang Liang, Jincheng Zeng, Shihong Shi, Faizan Alawi, Lee Carrasco, Qunzhou Zhang, Anh D Le

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ting-Han ChangDepartment of Oral and Maxillofacial Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8993-5678
Rabie M ShantiDepartment of Oral and Maxillofacial Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
Yanfang LiangDepartment of Pathology, Dongguan Hospital Affiliated to Medical College of Jinan University, The Fifth People's Hospital of Dongguan, Dongguan, 523905, China.
Jincheng ZengDepartment of Oral and Maxillofacial Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6196-3917
Shihong ShiDepartment of Oral and Maxillofacial Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
Faizan AlawiDepartment of Pathology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
Lee CarrascoDepartment of Oral and Maxillofacial Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
Qunzhou ZhangDepartment of Oral and Maxillofacial Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA. zqunzhou@upenn.edu.
Anh D LeDepartment of Oral and Maxillofacial Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA. Anh.Le@uphs.upenn.edu.
University of Pennsylvania · USHospital of the University of Pennsylvania · USGuangdong Medical College · CNJinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ameloblastoma (AM) is a benign but locally aggressive tumor with high recurrences. Currently, underlying pathophysiology remains elusive, and radical surgery remains the most definitive treatment with severe morbidities. We have recently reported that AM harbors a subpopulation of tumor epithelial stem-like cells (AM-EpiSCs). Herein, we explored whether LGR5

Indexed as

AmeloblastomaAnimalsCarcinogenesisCell Line, TumorCell ProliferationCell Self RenewalDrug Resistance, NeoplasmEpithelial CellsEpithelial-Mesenchymal TransitionMaleMice, NudeNeoplastic Stem CellsOrganoidsPhenotypeProto-Oncogene Proteins B-rafReceptors, G-Protein-CoupledBRAF protein, humanLGR5 protein, humanProto-Oncogene Proteins B-rafReceptors, G-Protein-CoupledThrombospondins

Identifiers

PMID32382005
PMCPMC7206107
OpenAlexW3021195728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.