Evidence map›Paper›PMID 32381722›Full record

ArticleScience (New York, N.Y.)2020

Light-powered CO

Tarryn E Miller, Thomas Beneyton, Thomas Schwander, Christoph Diehl, Mathias Girault, Richard McLean, Tanguy Chotel, Peter Claus, Niña Socorro Cortina, Jean-Christophe Baret and 1 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

125 citing papers in PubMed.

  1. Article
  2. Electrophile-Nucleophile Paired Heteronuclear Dual-Site for Selective COAngewandte Chemie (International ed. in English) · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Improving cell-free metabolism through direct integration of artificial respiratory chains.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Let There be Light! Light as an Engine and Regulator in Synthetic Cells.Angewandte Chemie (International ed. in English) · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Photocatalytic Biohybrid Vesicles.Chemical reviews · 2026
    Review
  16. Review
  17. Article
  18. Article
  19. A Robust Synthesis of Fluorosurfactants with Tunable Functionalities via a Two-Step Reaction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  20. Article

65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Tarryn E MillerDepartment of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, D-35043 Marburg, Germany.ORCID 0000-0003-2274-2083
Thomas BeneytonUniversity of Bordeaux, CNRS, Centre de Recherche Paul Pascal, UMR 5031, Pessac 33600, France.ORCID 0000-0003-2322-4886
Thomas SchwanderDepartment of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, D-35043 Marburg, Germany.ORCID 0000-0001-9201-3017
Christoph DiehlDepartment of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, D-35043 Marburg, Germany.
Mathias GiraultInstitut Universitaire de France, Paris 75005, France.
Richard McLeanDepartment of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, D-35043 Marburg, Germany.
Tanguy ChotelUniversity of Bordeaux, CNRS, Centre de Recherche Paul Pascal, UMR 5031, Pessac 33600, France.
Peter ClausDepartment of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, D-35043 Marburg, Germany.
Niña Socorro CortinaDepartment of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, D-35043 Marburg, Germany.ORCID 0000-0002-0930-660X
Jean-Christophe BaretUniversity of Bordeaux, CNRS, Centre de Recherche Paul Pascal, UMR 5031, Pessac 33600, France. toerb@mpi-marburg.mpg.de jean-christophe.baret@u-bordeaux.fr.ORCID 0000-0003-2048-8317
Tobias J ErbDepartment of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, D-35043 Marburg, Germany. toerb@mpi-marburg.mpg.de jean-christophe.baret@u-bordeaux.fr.ORCID 0000-0003-3685-0894

Funding

European Research Council 637675
6 · The paper itself

Abstract

Nature integrates complex biosynthetic and energy-converting tasks within compartments such as chloroplasts and mitochondria. Chloroplasts convert light into chemical energy, driving carbon dioxide fixation. We used microfluidics to develop a chloroplast mimic by encapsulating and operating photosynthetic membranes in cell-sized droplets. These droplets can be energized by light to power enzymes or enzyme cascades and analyzed for their catalytic properties in multiplex and real time. We demonstrate how these microdroplets can be programmed and controlled by adjusting internal compositions and by using light as an external trigger. We showcase the capability of our platform by integrating the crotonyl-coenzyme A (CoA)/ethylmalonyl-CoA/hydroxybutyryl-CoA (CETCH) cycle, a synthetic network for carbon dioxide conversion, to create an artificial photosynthetic system that interfaces the natural and the synthetic biological worlds.

Indexed as

Acyl Coenzyme ABiocatalysisBiomimeticsCarbon CycleCarbon DioxideChloroplastsLightPhotosynthesisSpinacia oleraceaAcyl Coenzyme ACarbon Dioxideethylmalonyl-coenzyme A

Identifiers

PMID32381722
PMCPMC7610767

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.