Evidence map›Paper›PMID 32381628›Full record

ArticleGenes & development2020

Transcriptional down-regulation of metabolic genes by Gdown1 ablation induces quiescent cell re-entry into the cell cycle.

Miki Jishage, Keiichi Ito, Chi-Shuen Chu, Xiaoling Wang, Masashi Yamaji, Robert G Roeder

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Miki JishageLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, USA.
Keiichi ItoLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, USA.
Chi-Shuen ChuLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, USA.
Xiaoling WangLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, USA.
Masashi YamajiDivision of Reproductive Sciences, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229, USA.ORCID 0000-0002-8215-2184
Robert G RoederLaboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10065, USA.
Rockefeller University · USCincinnati Children's Hospital Medical Center · US

Funding

Mechanisms of Cell Regulation and TransformationT32CA009673 · NCI · ROCKEFELLER UNIVERSITY · PI KAPOOR, TARUN M. · 1991 to 2018
$7.0M
Mechanisms of p53 target gene activation in DNA damage responsesR01CA129325 · NCI · ROCKEFELLER UNIVERSITY · PI ROEDER, ROBERT G · 2007 to 2011
$4.0M
Biological roles and Mediator-dependent transcription mechanisms of RNA polymerase II(G)R01CA202245 · NCI · ROCKEFELLER UNIVERSITY · PI ROEDER, ROBERT G · 2016 to 2020
$1.9M
NCI NIH HHS R01 CA129325NCI NIH HHS R01 CA202245NCI NIH HHS T32 CA009673
6 · The paper itself

Abstract

Liver regeneration and metabolism are highly interconnected. Here, we show that hepatocyte-specific ablation of RNA polymerase II (Pol II)-associated Gdown1 leads to down-regulation of highly expressed genes involved in plasma protein synthesis and metabolism, a concomitant cell cycle re-entry associated with induction of cell cycle-related genes (including

Indexed as

AnimalsCell CycleCell ProliferationDown-RegulationGene Expression Regulation, DevelopmentalGene Knockout TechniquesGenes, p53HepatocytesLiverRNA Polymerase IISignal TransductionPolr2m protein, mouseRNA Polymerase IIcancercell cyclemetabolismtranscription regulation

Identifiers

PMID32381628
PMCPMC7263145
OpenAlexW3022623604

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.