ArticleScience (New York, N.Y.)2020
PIRs mediate innate myeloid cell memory to nonself MHC molecules.
Open access · greenAbstract read
In one paragraph
Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 149 citations in OpenAlex.
- Innate Immune Memory Responses in Organ Transplantation.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- CD1d functions as a ligand for PIRA2 to drive macrophage activation in nonalcoholic fatty liver disease.Cell death & disease · 2026Article
- A Subset of Pro-inflammatory CXCL10+ LILRB2+ Macrophages Derives From Recipient Monocytes and Drives Renal Allograft Rejection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Recent perspectives on macrophage memory: types, mechanisms, and characteristics in pulmonary diseases.Cell communication and signaling : CCS · 2026Review
- Innovative approaches targeting innate immune cells to promote organ transplant tolerance.Frontiers in transplantation · 2026Review
- The authors respond to feedback onFrontiers in oncology · 2026Article
- Sensitization in Transplantation Assessment of Risk 2025 innate working group: The potential role of innate allorecognition in kidney allograft damage.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Review
- Role of autophagy in rejection after solid organ transplantation: A systematic review of the literature.World journal of transplantation · 2025Review
- Donor-recipient mismatch at theScience translational medicine · 2025Article
- Myeloid-specific deficiency of ribosomal protein L13a alters macrophage polarity and diversity during differentiation from bone marrow.Journal of leukocyte biology · 2025Article
- Setdb1 ablation in macrophages attenuates fibrosis in heart allografts.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Transforming heart transplantation care with multi-omics insights.Journal of translational medicine · 2025Review
- Adenosine triphosphate-mediated signaling of P2X7 receptors controls donor extracellular vesicle release and major histocompatibility complex cross-decoration after allotransplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025Article
- Chronic Lung Allograft Dysfunction: Clinical Manifestations and Immunologic Mechanisms.Transplantation · 2025Review
- Spatial transcriptomics reveals distinct role of monocytes/macrophages with highFrontiers in immunology · 2025Article
- Genetic variants of the HLA-G/LILRB1 ligand-receptor axis in donors or recipients are prognostic covariates for rejection after living kidney transplantation.Frontiers in immunology · 2025Article
- Mechanisms of allorecognition and xenorecognition in transplantation.Clinical transplantation and research · 2024Review
- Decoding the hallmarks of allograft dysfunction with a comprehensive pan-organ transcriptomic atlas.Nature medicine · 2024Article
- Strain-specific differences in reovirus infection of murine macrophages segregate with polymorphisms in viral outer-capsid protein σ3.Journal of virology · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Commented on by
Authors and funding
26 authors at 7 institutions in 4 countries.
Hehua Dai *Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-1595-5737
Peixiang Lan *Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX, USA.ORCID 0000-0001-7569-894X
Daqiang Zhao *Thomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-2582-0112
Khodor Abou-DayaThomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-8788-2728
Wentao LiuImmunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX, USA.
Wenhao ChenImmunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX, USA.
Andrew J FridayThomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Amanda L WilliamsThomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Tao SunDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Jianjiao ChenDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.
Wei ChenDepartment of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-7196-8703
Steven Mortin-TothProgram in Genetics and Genome Biology, Hospital for Sick Children Research Institute, Toronto, ON, Canada.ORCID 0000-0002-3029-1975
Jayne S DanskaProgram in Genetics and Genome Biology, Hospital for Sick Children Research Institute, Toronto, ON, Canada.ORCID 0000-0002-6549-4991
Chris WiebeDepartment of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Peter NickersonDepartment of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Tengfang LiThomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-6345-6716
Lisa R MathewsThomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Hêth R TurnquistThomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-4173-4014
Matthew L NicotraThomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-5361-8398
Sebastien GingrasDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-2607-8642
Eiji TakayamaDepartment of Oral Biochemistry, Asahi University School of Dentistry, Gifu, Japan.
Hiromi KubagawaHumoral Immune Regulation, Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany.
Mark J ShlomchikDepartment of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-2152-0959
Martin H OberbarnscheidtThomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA. mho6@pitt.edu xcli@houstonmethodist.org lakkisf@upmc.edu.ORCID 0000-0003-2040-809X
Xian C LiImmunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston, TX, USA. mho6@pitt.edu xcli@houstonmethodist.org lakkisf@upmc.edu.ORCID 0000-0002-5981-2762
Fadi G LakkisThomas E. Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA. mho6@pitt.edu xcli@houstonmethodist.org lakkisf@upmc.edu.ORCID 0000-0001-9937-2637
University of Pittsburgh · USHouston Methodist · USUniversity of Manitoba · CAAsahi University · JPGerman Rheumatism Research Centre · DEHospital for Sick Children · CAUniversity of Toronto · CA
Funding
Modulation of innate immune cells to create transplant toleranceR01AI080779 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI Xian Chang Li · 2011 to 2026
$5.2MImmunoregulatory Mechanisms of IL-33 in Heart TransplantationR01HL122489 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Heth R Turnquist · 2015 to 2026
$4.9MInnate Recognition of Allogeneic Non-SelfR01AI099465 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAKKIS, FADI G. · 2012 to 2022
$4.1MTertiary Lymphoid Organs in TransplantationR01AI145881 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OBERBARNSCHEIDT, MARTIN H · 2019 to 2023
$1.9MModulation of innate immune cells to create transplant toleranceR56AI080779 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LI, XIAN CHANG · 2010 to 2010
$435kCIHRNHLBI NIH HHS R01 HL122489NIAID NIH HHS R01 AI080779NIAID NIH HHS R01 AI099465NIAID NIH HHS R01 AI145881NIAID NIH HHS R56 AI080779
Abstract
Immunological memory specific to previously encountered antigens is a cardinal feature of adaptive lymphoid cells. However, it is unknown whether innate myeloid cells retain memory of prior antigenic stimulation and respond to it more vigorously on subsequent encounters. In this work, we show that murine monocytes and macrophages acquire memory specific to major histocompatibility complex I (MHC-I) antigens, and we identify A-type paired immunoglobulin-like receptors (PIR-As) as the MHC-I receptors necessary for the memory response. We demonstrate that deleting PIR-A in the recipient or blocking PIR-A binding to donor MHC-I molecules blocks memory and attenuates kidney and heart allograft rejection. Thus, innate myeloid cells acquire alloantigen-specific memory that can be targeted to improve transplant outcomes.
Indexed as
Immunity, InnateImmunologic MemoryAnimalsGene DeletionGraft RejectionHeart TransplantationHistocompatibility Antigens Class IKidney TransplantationMacrophagesMiceMice, Inbred BALB CMice, Mutant StrainsMonocytesReceptors, ImmunologicHistocompatibility Antigens Class IPira1 protein, mousePira3 protein, mouseReceptors, ImmunologicSirpa protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.