Evidence map›Paper›PMID 32381561›Full record

ArticleAnnals of the rheumatic diseases2020

Baseline use of hydroxychloroquine in systemic lupus erythematosus does not preclude SARS-CoV-2 infection and severe COVID-19.

Maximilian F Konig, Alfred Hj Kim, Marc H Scheetz, Elizabeth R Graef, Jean W Liew, Julia Simard, Pedro M Machado, Milena Gianfrancesco, Jinoos Yazdany, Daman Langguth and 2 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the rheumatic diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Observational
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. COVID-19 therapeutics: Challenges and directions for the future.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Review
  12. Article
  13. Article
  14. Review
  15. Observational
  16. Article
  17. Article
  18. COVID-19 in patients with systemic lupus erythematosus: lessons learned from the inflammatory disease.Translational research : the journal of laboratory and clinical medicine · 2021
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Maximilian F KonigDivision of Rheumatology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA konig@jhmi.edu philip.robinson@uq.edu.au.ORCID 0000-0001-5045-5255
Alfred Hj KimDivision of Rheumatology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.ORCID 0000-0003-4074-0516
Marc H ScheetzDepartments of Pharmacy Practice and Pharmacology; Pharmacometrics Center of Excellence, Midwestern University, Chicago College of Pharmacy, and College of Graduate Studies, Downers Grove, Illinois, USA.
Elizabeth R GraefDivision of Rheumatology and Clinical Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Jean W LiewDivision of Rheumatology, Department of Medicine, University of Washington, Seattle, Washington, USA.
Julia SimardDepartment of Epidemiology & Population Health; Department of Medicine, Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, California, USA.
Pedro M MachadoCentre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, UK.ORCID 0000-0002-8411-7972
Milena GianfrancescoDivision of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Jinoos YazdanyDivision of Rheumatology, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Daman LangguthDepartment of Immunology, Sullivan Nicolaides Pathology, Brisbane, Queensland, Australia.
Philip C RobinsonThe University of Queensland Faculty of Medicine, Brisbane, Queensland, Australia konig@jhmi.edu philip.robinson@uq.edu.au.ORCID 0000-0002-3156-3418
COVID-19 Global Rheumatology Alliance

Funding

RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGYP30AR070155 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mary C Nakamura · 2016 to 2026
$8.2M
Washington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Christine T. Pham · 2018 to 2026
$7.6M
Multidisciplinary Rheumatology Training ProgramT32AR048522 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI CLIFTON O BINGHAM, LIVIA A CASCIOLA-ROSEN · 2003 to 2026
$6.4M
Advancing Quality and Outcomes Measurement in RheumatologyK24AR074534 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jinoos Yazdany · 2019 to 2026
$1.5M
Computational methods using electronic health records and registry data to detect and predict clinical outcomes in rheumatic diseaseK01AR075085 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GIANFRANCESCO, MILENA ANNE · 2019 to 2022
$458k
NIAMS NIH HHS K01 AR075085NIAMS NIH HHS K24 AR074534NIAMS NIH HHS L30 AR072421NIAMS NIH HHS P30 AR070155NIAMS NIH HHS P30 AR073752NIAMS NIH HHS T32 AR048522
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAntirheumatic AgentsBetacoronavirusCase-Control StudiesCoronavirus InfectionsCOVID-19Dose-Response Relationship, DrugExtracorporeal Membrane OxygenationFemaleHospitalizationHumansHydroxychloroquineLupus Erythematosus, SystemicMaleMiddle AgedAntirheumatic AgentsHydroxychloroquineepidemiologyhydroxychloroquinelupus erythematosus, systemicpharmacokinetics

Identifiers

PMID32381561
PMCPMC8258626

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.