ArticleAJNR. American journal of neuroradiology2020
Effect of Age on GABA+ and Glutathione in a Pediatric Sample.
Article in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
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Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Developmental Alterations in the Diffusion Tensor Imaging Analysis Along the Perivascular Space Index Suggest Possible Glymphatic-Related Mechanisms Underlying Excitation/Inhibition Imbalance and Psychosis Vulnerability in 22q11.2 Deletion Syndrome.Biological psychiatry global open science · 2026Article
- Longitudinal changes in neurometabolites in pediatric migraine across child development: a pilot study.Scientific reports · 2026Article
- Myo-Inositol Levels in the Dorsal Anterior Cingulate Cortex Are Associated With Anxiety-to-Eat in Anorexia Nervosa.The International journal of eating disorders · 2026Article
- Proton Magnetic Resonance Spectroscopy for Pediatric Neuroimaging: Key Concepts for Practice.Seminars in ultrasound, CT, and MR · 2025Review
- Lower distress intolerance is associated with higher glutathione levels in adolescent cannabis users.Pharmacology, biochemistry, and behavior · 2024Article
- GABA and glutamate measurements in temporal cortex of autistic children.Autism research : official journal of the International Society for Autism Research · 2024Article
- The Impact of Bioactive Molecules from Probiotics on Child Health: A Comprehensive Review.Nutrients · 2024Review
- GABA (gamma-aminobutyric acid) levels in dorsal anterior cingulate cortex are negatively associated with food motivation in a pediatric sample.Scientific reports · 2024Article
- Brain extended and closed forms glutathione levels decrease with age and extended glutathione is associated with visuospatial memory.NeuroImage · 2024Article
- Brain glutathione and GABA+ levels in autistic children.Autism research : official journal of the International Society for Autism Research · 2024Article
- Atypical Tactile Perception in Early Childhood Autism.Journal of autism and developmental disorders · 2023Article
- Cortical excitability in human somatosensory and visual cortex: implications for plasticity and learning - a minireview.Frontiers in human neuroscience · 2023Review
- Nonlinear age effects in tactile processing from early childhood to adulthood.Brain and behavior · 2022Article
- Examination of gamma-aminobutyric acid and glutamate-glutamine levels in association with impulsive behavior in adolescent marijuana users.Drug and alcohol dependence · 2022Article
- The macromolecular MR spectrum does not change with healthy aging.Magnetic resonance in medicine · 2022Article
- Edited magnetic resonance spectroscopy in the neonatal brain.Neuroradiology · 2022Review
- GABA and glutamate in the preterm neonatal brain: In-vivo measurement by magnetic resonance spectroscopy.NeuroImage · 2021Review
- In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Macromolecule suppressed GABA levels show no relationship with age in a pediatric sample.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
background and purposeGamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the human brain and is implicated in several neuropathologies. Glutathione is a major antioxidant in the brain and is considered a marker of oxidative stress. Several studies have reported age-related declines in GABA levels in adulthood, but the trajectory of both GABA and glutathione during childhood has not been well explored. The aim of this study is to establish how GABA and glutathione vary with age during early development. MATERIALS AND
methodsTwenty-three healthy children (5.6-13.9 years of age) were recruited for this study. MR imaging/MR spectroscopy experiments were conducted on a 3T MR scanner. A 27-mL MR spectroscopy voxel was positioned in the frontal lobe. J-difference edited MR spectroscopy was used to spectrally edit GABA and glutathione. Data were analyzed using the Gannet software, and GABA+ (GABA + macromolecules/homocarnosine) and glutathione were quantified using water (GABA+
resultsBoth GABA+
conclusionsWe demonstrate increases in GABA and no differences in glutathione with age in a healthy pediatric sample. This study provides insight into neuronal maturation in children and may facilitate better understanding of normative behavioral development and the pathophysiology of developmental disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.