Evidence map›Paper›PMID 32381542›Full record

ArticleAJNR. American journal of neuroradiology2020

Structural Connectivity and Cortical Thickness Alterations in Transient Global Amnesia.

J Hodel, X Leclerc, M Zuber, S Gerber, P Besson, V Marcaud, V Roubeau, H Brasme, I Ganzoui, D Ducreux and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

J HodelFrom the Departments of Radiology (J.H., S.G., I.G., M.Z.) jerome.hodel@gmail.com.ORCID 0000-0002-9029-6890
X LeclercDepartment of Neuroradiology (X.L., J.-P.P., R.L.), Roger Salengro Hospital, Lille, France.ORCID 0000-0002-0922-7661
M ZuberNeurology (M.Z., V.M., V.R., H.B.), Saint Joseph Hospital, Paris, France.ORCID 0000-0002-4049-2746
S GerberFrom the Departments of Radiology (J.H., S.G., I.G., M.Z.).ORCID 0000-0002-1901-8126
P BessonDepartment of Radiology (P.B.), Northwestern University, Feinberg School of Medicine, Chicago, Illinois.ORCID 0000-0002-0591-7542
V MarcaudNeurology (M.Z., V.M., V.R., H.B.), Saint Joseph Hospital, Paris, France.ORCID 0000-0001-8723-0818
V RoubeauNeurology (M.Z., V.M., V.R., H.B.), Saint Joseph Hospital, Paris, France.ORCID 0000-0003-1498-8307
H BrasmeNeurology (M.Z., V.M., V.R., H.B.), Saint Joseph Hospital, Paris, France.ORCID 0000-0002-7312-2995
I GanzouiFrom the Departments of Radiology (J.H., S.G., I.G., M.Z.).ORCID 0000-0002-0804-3051
D DucreuxDepartment of Neuroradiology (D.D.), Bicêtre Hospital, Kremlin-Bicêtre, France.ORCID 0000-0003-1806-3475
J-P PruvoDepartment of Neuroradiology (X.L., J.-P.P., R.L.), Roger Salengro Hospital, Lille, France.ORCID 0000-0001-8335-4872
M BertouxUniversity of Lille (M.B., R.L.), Inserm U1171, CHU Lille, F-59000, Lille, France.ORCID 0000-0002-5283-503X
M ZinsFrom the Departments of Radiology (J.H., S.G., I.G., M.Z.).ORCID 0000-0001-5694-1238
R LopesDepartment of Neuroradiology (X.L., J.-P.P., R.L.), Roger Salengro Hospital, Lille, France.ORCID 0000-0002-2425-2283
GfK (United States) · USHôpital Paris Saint-Joseph · FRHôpital Roger Salengro · FRInserm · FRBicêtre Hospital · FRCentre Intégré de Santé et de Services Sociaux des Laurentides · CADélégation Paris 5 · FRNorthwestern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeTransient global amnesia (TGA) is a sudden onset of anterograde and retrograde amnesia. We aimed to assess differences in terms of cortical thickness and structural brain connectome between patients with TGA (at acute and delayed postrecovery stages) and matched controls. MATERIALS AND

methodsWe report on 18 consecutive patients with TGA who underwent 3T MR imaging, including DTI and MPRAGE sequences, at the acute (mean delay postonset: 44 hours) and delayed post-recovery (mean delay: 35 days) stages. Structural connectome was assessed in patients with TGA and in 18 age- and sex-matched controls by using probabilistic fiber- tracking and segmentation of 164 cortical/subcortical structures ("nodes"). Connectivity graphs were computed and global network metrics were calculated. Network-based statistical analysis (NBS) was applied to compare patients with TGA at each stage with controls. We also compared cortical thickness between patients with TGA and healthy controls.

resultsGlobal network metrics were not altered in patients with TGA. NBS-analysis showed structural connectome alterations in patients with TGA compared with controls, in core regions involving the limbic network, with 113 nodes and 114 connections (33 left intrahemispheric, 31 right intrahemispheric, and 50 interhemispheric connections) showing significantly decreased structural connectivity (

conclusionsOur preliminary study suggests there are structural abnormalities of the limbic network in patients with TGA compared with controls, including decreased structural connectivity and cortical thickness.

Indexed as

AdultAgedAged, 80 and overAmnesia, Transient GlobalConnectomeFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle Aged

Identifiers

PMID32381542
PMCPMC7228167
OpenAlexW3021020333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.