ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
The Nucleus Accumbens Core is Necessary to Scale Fear to Degree of Threat.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Social Novelty Recruits a Dysfunctional Nucleus Accumbens Ensemble That Drives Social Avoidance in abioRxiv : the preprint server for biology · 2026Article
- Perceived Racism, Brain Development, and Internalizing and Externalizing Symptoms: Findings From the ABCD Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Sex-specific exploration accounts for differences in valence learning in male and female mice.eLife · 2025Article
- Paraventricular thalamic inputs to the ventral pallidum shape reward seeking during threat and fear responding in extinction.Behavioral neuroscience · 2025Article
- Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology.Development and psychopathology · 2025Article
- Assessing the role of BNST GABA neurons in backward conditioned suppression.Neurobiology of learning and memory · 2025Article
- 22 and 50 kHz rat ultrasonic vocalization playback reveals sex differences in behavior and cFos in brain regions associated with affective processing.Behavioural brain research · 2025Article
- Translational approaches to the neurobiological study of conditional discrimination and inhibition: Implications for psychiatric disease.Behavioral neuroscience · 2024Review
- Article
- D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning.Neuron · 2024Article
- The Dichotomy of Threat and Deprivation as Subtypes of Childhood Maltreatment: Differential Functional Connectivity Patterns of Threat and Reward Circuits in an Adult Trauma Sample.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Conditioned inhibition of fear and reward in male and female rats.Neurobiology of learning and memory · 2024Article
- The nucleus accumbens in reward and aversion processing: insights and implications.Frontiers in behavioral neuroscience · 2024Review
- Nucleus accumbens local circuit for cue-dependent aversive learning.Cell reports · 2023Article
- Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety.Behavioral neuroscience · 2023Article
- Anxiety in synucleinopathies: neuronal circuitry, underlying pathomechanisms and current therapeutic strategies.NPJ Parkinson's disease · 2023Review
- Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety.bioRxiv : the preprint server for biology · 2023Article
- Timing of behavioral responding to long-duration Pavlovian fear conditioned cues.bioRxiv : the preprint server for biology · 2023Article
- Differentiating distinct and converging neural correlates of types of systemic environmental exposures.Human brain mapping · 2022Article
- Computational modeling of threat learning reveals links with anxiety and neuroanatomy in humans.eLife · 2022Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
Fear is adaptive when the level of the response rapidly scales to degree of threat. Using a discrimination procedure consisting of danger, uncertainty, and safety cues, we have found rapid fear scaling (within 2 s of cue presentation) in male rats. Here, we examined a possible role for the nucleus accumbens core (NAcc) in the acquisition and expression of fear scaling. In experiment 1, male Long-Evans rats received bilateral sham or neurotoxic NAcc lesions, recovered, and underwent fear discrimination. NAcc-lesioned rats were generally impaired in scaling fear to degree of threat, and specifically impaired in rapid uncertainty-safety discrimination. In experiment 2, male Long-Evans rats received NAcc transduction with halorhodopsin (Halo) or a control fluorophore. After fear scaling was established, the NAcc was illuminated during cue or control periods. NAcc-Halo rats receiving cue illumination were specifically impaired in rapid uncertainty-safety discrimination. The results reveal a general role for the NAcc in scaling fear to degree of threat, and a specific role in rapid discrimination of uncertain threat and safety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.