ArticleAmerican journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics2020
Root resorption and ensuing cementum repair by Wnt/β-catenin dependent mechanism.
Article in American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 32 citations in OpenAlex.
- Roles of Wnt signaling pathway in cementum formation, cementum regeneration, and cementocyte function.Journal of Zhejiang University. Science. B · 2026Review
- Piezo1/PI3K-induced autophagy dysregulation in PDLSCs under mechanical stress during root resorption.Journal of molecular medicine (Berlin, Germany) · 2026Article
- The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats.International journal of oral science · 2024Article
- Olanzapine decreased osteocyte maturation and Wnt/β-catenin signaling during loading of the alveolar bone in rats.Biomolecules & biomedicine · 2023Article
- Connective tissue growth factor promotes cementogenesis and cementum repair via Cx43/β-catenin axis.Stem cell research & therapy · 2022Article
- Effect of the Number of Micro-Osteoperforations on the Rate of Tooth Movement and Periodontal Response in Mice.Frontiers in physiology · 2022Article
- Advances in the Study of the Mechanisms of Physiological Root Resorption in Deciduous Teeth.Frontiers in pediatrics · 2022Review
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
introductionPhysiological root resorption is a common occurrence in mammalian teeth, which suggests that there must be a corollary consisting of physiological cementum repair. The mechanism(s) responsible for this physiological repair process is unknown and was the focus of this study.
methodsUsing a rat model, we explored first the prevalence of physiological root resorption and then asked whether this prevalence changed as a result of an osteoporotic phenotype. The cellular mechanisms of resorption were characterized using a combination of finite element modeling coupled with in-vivo histologic, molecular, and cellular analyses in rats. A potential molecular mechanism for cementum repair was uncovered using a strain of transgenic mice in which Wnt-responsive cells could be labeled and followed over time.
resultsIn rats, most resorption lacunae were concentrated on the distal surfaces of the roots. Rat molars undergo a physiological tooth drift distally, and using finite element modeling, we calculated the magnitude of the compressive strains that accumulated on these surfaces in response to mastication. Although the overall strain magnitudes were low, they were constant and coincided with the presence of resorption lacunae. Where resorption lacunae were present, progeny from a Wnt-responsive population of stem cells, embedded in the periodontal ligament, directly contributed to the repair of the lacunae.
conclusionsDespite the fact that both are clastic conditions, an osteoporotic phenotype in rats was not associated with an increase in the prevalence of physiological root resorption. The location of the resorption lacunae corresponded to sites of low but constant compressive strains produced by physiological distal drift. At least 1 mechanism responsible for physiological cementum repair involved the contribution of Wnt-responsive stem or progenitor cells originating in the periodontal ligament. These data point toward a potential Wnt-based strategy to regenerate cementum in subjects with disease or damage.
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