ArticleJournal of the American College of Cardiology2020
Incidence and Long-Term Outcomes of Hypertensive Disorders of Pregnancy.
Article in Journal of the American College of Cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 205 papers, 9 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
205 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- Hemodynamics-guided therapy for hypertensive disorders of pregnancy: a systematic review.Archives of gynecology and obstetrics · 2026Pooled it
- Structured exercise interventions for women at high risk of or diagnosed with hypertensive disorders of pregnancy: a scoping review.Frontiers in cardiovascular medicine · 2026Pooled it
- Atherosclerosis after pre-eclampsia: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Pooled it
- Factors related to postpartum length of stay in women with pre-eclampsia: a systematic review.BMC pregnancy and childbirth · 2025Pooled it
- Associations between adverse pregnancy outcomes and cognitive impairment and dementia: a systematic review and meta-analysis.The lancet. Healthy longevity · 2024Pooled it
- Hypertensive disorders of pregnancy and the risk of dementia: a systematic review and meta-analysis of cohort studies.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Pooled it
- Polygenic prediction of preeclampsia and gestational hypertension.Nature medicine · 2023Pooled it
- Primary Care-Based Cardiovascular Disease Risk Management After Adverse Pregnancy Outcomes: a Narrative Review.Journal of general internal medicine · 2022Pooled it
- The Association Between Hypertensive Disorders in Pregnancy and the Risk of Developing Chronic Hypertension.Frontiers in cardiovascular medicine · 2022Pooled it
- Feasibility of multi-component intervention for blood pressure control in pregnancy in Nigeria and Ghana: a pilot randomized clinical trial.BMC pregnancy and childbirth · 2026Trial
- Randomized Study of Antithrombin in Early-Onset Preeclampsia: KOUNO-TORI Study.Hypertension (Dallas, Tex. : 1979) · 2026Trial
- The Association between Nutrition, Physical Activity, and Cardiometabolic Health at 6 Months following a Hypertensive Pregnancy: A BPNutrients · 2023Trial
- Pre-Eclampsia and Maternal Cardiovascular Function: Insights Into Pathophysiology and Care (Scientific Impact Paper No. 79).BJOG : an international journal of obstetrics and gynaecology · 2026Article
- Hypertensive Disorders of Pregnancy and Cardiovascular-Kidney-Metabolic Syndrome.Hypertension (Dallas, Tex. : 1979) · 2026Article
- The endothelin-1/TLR4/NF-κB/NLRP3 inflammasome axis in preeclampsia: a review of a pathological feed-forward loop and therapeutic frontier.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Hypertensive Disorders of Pregnancy and Incident Dementia.JAMA network open · 2026Article
- Preconception cardiometabolic markers and odds of developing adverse pregnancy outcomes: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).American journal of preventive cardiology · 2026Article
- Influence of Enhanced Administrative Case-Finding Strategies on Prevalence of Hypertensive Disorders of Pregnancy in Ontario: A Population-Based Descriptive Study.Journal of the American Heart Association · 2026Article
- Long-term neurological consequences of hypertensive disorders of pregnancy: Implications for postpartum monitoring and intervention.World journal of methodology · 2026Article
- Beyond the Agatston score: unmasking the metabolic and cellular imprint of coronary artery calcification in postmenopausal women.American journal of physiology. Heart and circulatory physiology · 2026Article
145 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundHypertensive disorders of pregnancy (HDP) are associated with increased risks for cardiovascular disease later in life. The HDP incidence is commonly assessed using diagnostic codes, which are not reliable; and typically are expressed per-pregnancy, which may underestimate the number of women with an HDP history after their reproductive years.
objectivesThis study sought to determine the incidence of HDP expressed as both per-pregnancy and per-woman, and to establish their associations with future chronic conditions and multimorbidity, a measure of accelerated aging, in a population-based cohort study.
methodsUsing the Rochester Epidemiology Project medical record-linkage system, the authors identified residents of Olmsted County, Minnesota, who delivered between 1976 and 1982. The authors classified pregnancies into normotensive, gestational hypertension, pre-eclampsia, eclampsia, pre-eclampsia superimposed on chronic hypertension, and chronic hypertension using a validated electronic algorithm, and calculated the incidence of HDP both per-pregnancy and per-woman. The risk of chronic conditions between women with versus those without a history of HDP (age and parity 1:2 matched) was quantified using the hazard ratio and corresponding 95% confidence interval estimated from a Cox model.
resultsAmong 9,862 pregnancies, we identified 719 (7.3%) with HDP and 324 (3.3%) with pre-eclampsia. The incidence of HDP and pre-eclampsia doubled when assessed on a per-woman basis: 15.3% (281 of 1,839) and 7.5% (138 of 1,839), respectively. Women with a history of HDP were at increased risk for subsequent diagnoses of stroke (hazard ratio [HR]: 2.27; 95% confidence interval [CI]: 1.37 to 3.76), coronary artery disease (HR: 1.89; 95% CI: 1.26 to 2.82), cardiac arrhythmias (HR: 1.62; 95% CI: 1.28 to 2.05), chronic kidney disease (HR: 2.41; 95% CI: 1.54 to 3.78), and multimorbidity (HR: 1.25; 95% CI: 1.15 to 1.35).
conclusionsThe HDP population-based incidence expressed per-pregnancy underestimates the number of women affected by this condition during their reproductive years. A history of HDP confers significant increase in risks for future chronic conditions and multimorbidity.
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