ArticleParticle and fibre toxicology2020
Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes.
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Article in Particle and fibre toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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23citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Nanoparticle-Based Therapies for Myocardial Injury and Heart Failure: A Systematic Review and Translational Appraisal of Preclinical Evidence.Biomolecules · 2026Pooled it
- Nanoparticle-Based Targeted Drug-Delivery Systems for Cardiomyopathy: Mechanisms and Therapeutic Advances.Molecules (Basel, Switzerland) · 2026Review
- An Integrated Cardiac Microtissue Proteome Map Extends Therapeutic Remodeling by Nanovesicles.Molecular & cellular proteomics : MCP · 2026Article
- Cardiovascular Nanomedicine: Breakthroughs in Therapy-Challenges in Safety and Cardiotoxic Risks: A Comprehensive Review of Inorganic Nanoparticles.Cardiovascular toxicology · 2026Review
- PKA activation rescues myocardial injury elicited by silica nanoparticles through improving oxidative stress, mitochondrial health, and copper homeostasis.Materials today. Bio · 2026Article
- MitoQ Protects Against Oxidative Stress-Induced Mitochondrial Dysregulation in Human Cardiomyocytes.Journal of molecular and cellular cardiology plus · 2025Article
- Understanding the Mechanism of Cardiotoxicity Induced by Nanomaterials: A Comprehensive Review.Small science · 2025Review
- Angiotensin II-Induced Hypertrophy in H9c2 Cells Reveals Severe Cytotoxicity of Graphene Oxide.ACS omega · 2025Article
- Study on the Regulated Cell Death of Hypertrophic H9c2 Cells Induced by Au:Ag Nanoparticles.International journal of nanomedicine · 2025Article
- Ferroptosis contributing to cardiomyocyte injury induced by silica nanoparticles via miR-125b-2-3p/HO-1 signaling.Particle and fibre toxicology · 2024Article
- State of the Art of Silica Nanoparticles: An Overview on Biodistribution and Preclinical Toxicity Studies.The AAPS journal · 2024Review
- Unexpected Inhibitory Role of Silica Nanoparticles on Lung Cancer Development by Promoting M1 Polarization of Macrophages.International journal of nanomedicine · 2024Article
- Cardiomyocyte intercellular signalling increases oxidative stress and reprograms the global- and phospho-proteome of cardiac fibroblasts.Journal of extracellular biology · 2023Article
- Application of Single Particle ICP-MS for the Determination of Inorganic Nanoparticles in Food Additives and Food: A Short Review.Nanomaterials (Basel, Switzerland) · 2023Review
- Exploiting Mass Spectrometry to Unlock the Mechanism of Nanoparticle-Induced Inflammasome Activation.ACS nano · 2023Article
- Synthesis and Characterization of Rutile TiOACS omega · 2023Article
- Post-translational modifications and protein quality control of mitochondrial channels and transporters.Frontiers in cell and developmental biology · 2023Review
- Scalable Generation of Nanovesicles from Human-Induced Pluripotent Stem Cells for Cardiac Repair.International journal of molecular sciences · 2022Article
- Reciprocal regulation of NRF2 by autophagy and ubiquitin-proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles.Journal of nanobiotechnology · 2022Article
- Mitochondrial Dysfunction in Cardiovascular Diseases: Potential Targets for Treatment.Frontiers in cell and developmental biology · 2022Review
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 6 countries.
Omar LozanoTecnologico de Monterrey. Escuela Nacional de Medicina y Ciencias de la Salud, Cátedra de Cardiología y Medicina Vascular, Monterrey, Mexico.
Christian Silva-PlatasTecnologico de Monterrey. Escuela Nacional de Medicina y Ciencias de la Salud, Cátedra de Cardiología y Medicina Vascular, Monterrey, Mexico.
Héctor Chapoy-VillanuevaTecnologico de Monterrey. Escuela Nacional de Medicina y Ciencias de la Salud, Cátedra de Cardiología y Medicina Vascular, Monterrey, Mexico.
Baruc E PérezTecnologico de Monterrey. Escuela Nacional de Medicina y Ciencias de la Salud, Cátedra de Cardiología y Medicina Vascular, Monterrey, Mexico.
Jarmon G LeesDepartments of Medicine and Surgery, University of Melbourne, Melbourne, Victoria, Australia.
Chrishan J A RamachandraNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.
Flavio F Contreras-TorresTecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Monterrey, Mexico.
Anay Lázaro-AlfaroTecnologico de Monterrey. Escuela Nacional de Medicina y Ciencias de la Salud, Cátedra de Cardiología y Medicina Vascular, Monterrey, Mexico.
Estefanía Luna-FigueroaTecnologico de Monterrey. Escuela Nacional de Medicina y Ciencias de la Salud, Cátedra de Cardiología y Medicina Vascular, Monterrey, Mexico.
Judith Bernal-RamírezTecnologico de Monterrey. Escuela Nacional de Medicina y Ciencias de la Salud, Cátedra de Cardiología y Medicina Vascular, Monterrey, Mexico.
Aldemar Gordillo-GaleanoDepartment of Physics and Astronomy, The University of Texas at San Antonio, San Antonio, USA.
Alfredo BenitezDepartment of Physics and Astronomy, The University of Texas at San Antonio, San Antonio, USA.
Yuriana Oropeza-AlmazánTecnologico de Monterrey. Escuela Nacional de Medicina y Ciencias de la Salud, Cátedra de Cardiología y Medicina Vascular, Monterrey, Mexico.
Elena C CastilloTecnologico de Monterrey. Escuela Nacional de Medicina y Ciencias de la Salud, Cátedra de Cardiología y Medicina Vascular, Monterrey, Mexico.
Poh Ling KohCardiovascular and Metabolic Disorders Programme, Duke-NUS Medical School, Singapore, Singapore.
Derek J HausenloyNational Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore.
Shiang Y LimDepartments of Medicine and Surgery, University of Melbourne, Melbourne, Victoria, Australia.
Gerardo García-RivasTecnologico de Monterrey. Escuela Nacional de Medicina y Ciencias de la Salud, Cátedra de Cardiología y Medicina Vascular, Monterrey, Mexico. gdejesus@tec.mx.ORCID 0000-0003-4731-3293
Tecnológico de Monterrey · MXDuke-NUS Medical School · SGHospital Zambrano Hellion · MXThe University of Melbourne · AUThe University of Texas at San Antonio · USAsia University · TW
Funding
STRUCTURAL VISUALIZATION IN BIOINFORMATICSG12RR013646 · NCRR · UNIVERSITY OF TEXAS SAN ANTONIO · PI ZHANG, JI · 1998 to 2011
$19.6MRCMI Center for Interdiscplinary Health Research CIHRG12MD007591 · NIMHD · UNIVERSITY OF TEXAS SAN ANTONIO · PI PERRY, GEORGE · 2012 to 2016
$10.4MBritish Heart Foundation CS/14/3/31002Department of HealthNCRR NIH HHS G12 RR013646NIMHD NIH HHS G12 MD007591
Abstract
backgroundSilica nanoparticles (nanoSiO
resultsThe cumulative administration of nanoSiO
conclusionThe aforementioned effects can be partially avoided reducing ROS or retarding the opening of the mPTP. These novel strategies which resulted in cardioprotection could be considered as potential therapies to decrease the side effects of nanoSiO
Indexed as
Adenosine TriphosphateAnimalsCells, CulturedCell SurvivalDose-Response Relationship, DrugHeartHumansMaleMembrane Potential, MitochondrialMitochondrial Permeability Transition PoreMyocardiumMyocytes, CardiacNanoparticlesOxidative StressParticle SizeRatsAdenosine TriphosphateMitochondrial Permeability Transition PoreReactive Oxygen SpeciesSilicon DioxideCalcium overloadCardiotoxicityHeartMitochondriaOxidative stressPermeability transitionSilica nanoparticles
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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.