Evidence map›Paper›PMID 32380957›Full record

SynthesisBMC infectious diseases2020

Tuberculosis and its association with CD4

Demeke Geremew, Mulugeta Melku, Aklilu Endalamaw, Berhanu Woldu, Alebachew Fasil, Markos Negash, Habtamu Wondifraw Baynes, Habtamu Geremew, Takele Teklu, Tekalign Deressa and 2 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 6 pooled it
0.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 6 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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  16. Exosomal microRNAs associated with tuberculosis among people living with human immunodeficiency virus.Journal of clinical tuberculosis and other mycobacterial diseases · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Demeke GeremewDepartment of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, University of Gondar, P.o.Box: 196, Gondar, Ethiopia. deme2112@gmail.com.
Mulugeta MelkuDepartment of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, University of Gondar, Gondar, Ethiopia.
Aklilu EndalamawDepartment of Pediatrics and Child Health Nursing, School of Health Sciences, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Berhanu WolduDepartment of Hematology and Immunohematology, School of Biomedical and Laboratory Sciences, University of Gondar, Gondar, Ethiopia.
Alebachew FasilDepartment of Clinical Chemistry, School of Biomedical and Laboratory Sciences, University of Gondar, Gondar, Ethiopia.
Markos NegashDepartment of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, University of Gondar, P.o.Box: 196, Gondar, Ethiopia.
Habtamu Wondifraw BaynesDepartment of Clinical Chemistry, School of Biomedical and Laboratory Sciences, University of Gondar, Gondar, Ethiopia.
Habtamu GeremewDepartment of Reproductive Health, School of Public Health, Debre Markos University, Debre Markos, Ethiopia.
Takele TekluDepartment of Immunology and Molecular Biology, School of Biomedical and Laboratory Sciences, University of Gondar, P.o.Box: 196, Gondar, Ethiopia.
Tekalign DeressaEthiopian Public Health Institute, HIV/AIDS and TB Research Directorate, Addis Ababa, Ethiopia.
Belay TessemaDepartment of Medical Microbiology, School of Biomedical and Laboratory Sciences, University of Gondar, Gondar, Ethiopia.
Ulrich SackInstitute of Clinical Immunology, Medical Faculty, University of Leipzig, Leipzig, Germany.
University of Gondar · ETBahir Dar University · ETDebre Markos University · ETEthiopian Public Health Institute · ETLeipzig University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTuberculosis (TB) and HV have been intertwined and makeup a deadly human syndemic worldwide, especially in developing countries like Ethiopia. Previous studies have reported different TB incidences and its association with CD4

methodsWe searched PubMed, Cochrane library, Science Direct and Google scholar databases from June 1 to 30, 2018. The I

resultsA total of 403 research articles were identified, and 10 studies were included in the meta-analysis. The pooled incident TB among adult HIV infected patients in Ethiopia was 16.58% (95% CI; 13.25-19.91%). Specifically, TB incidence in Pre-ART and ART was 17.16% (95% CI; 7.95-26.37%) and 16.24% (95% CI; 12.63-19.84%) respectively. Moreover, incident TB among ART receiving patients with baseline CD4

conclusionHigh incident TB among adult HIV positive patients was estimated, especially in patients with CD4

trial registrationStudy protocol registration: CRD42018090802.

Indexed as

CD4 Lymphocyte CountAdolescentAdultAIDS-Related Opportunistic InfectionsEthiopiaHIV InfectionsHIV SeropositivityHumansIncidenceMiddle AgedOdds RatioPatient ComplianceRisk FactorsTuberculosisYoung AdultCD4+ T cellEthiopiaHIVMeta-analysisTuberculosis

Identifiers

PMID32380957
PMCPMC7204319
OpenAlexW3023135186

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.