Evidence map›Paper›PMID 32380800›Full record

ArticleThe Korean journal of internal medicine2020

J-curve relationship between corrected QT interval and mortality in acute heart failure patients.

Chan Soon Park, Hyun-Jai Cho, Eue-Keun Choi, Sang Eun Lee, Min-Seok Kim, Jae-Joong Kim, Jin-Oh Choi, Eun-Seok Jeon, Kyung-Kuk Hwang, Shung Chull Chae and 9 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Korean journal of internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Observational
  2. QT interval and short-term outcome in acute heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2023
    Article
  3. Article
  4. Observational
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 13 institutions in 1 country.

Chan Soon ParkGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Hyun-Jai ChoDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Eue-Keun ChoiDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Sang Eun LeeDivision of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Min-Seok KimDivision of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jae-Joong KimDivision of Cardiology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Jin-Oh ChoiDepartment of Internal Medicine, Sungkyunkwan University College of Medicine, Seoul, Korea.
Eun-Seok JeonDepartment of Internal Medicine, Sungkyunkwan University College of Medicine, Seoul, Korea.
Kyung-Kuk HwangDepartment of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
Shung Chull ChaeDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Sang Hong BaekDepartment of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Seok-Min KangDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Byungsu YooDepartment of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Dong-Ju ChoiCardiovascular Center, Division of Cardiology, Seoul National University Bundang Hospital, Seongnam, Korea.
Youngkeun AhnHeart Research Center, Chonnam National University, Gwangju, Korea.
Kye-Hoon KimHeart Research Center, Chonnam National University, Gwangju, Korea.
Myeong-Chan ChoDepartment of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
Byung-Hee OhDepartment of Internal Medicine, Mediplex Sejong Hospital, Incheon, Korea.
Hae-Young LeeDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Seoul National University Hospital · KRChonnam National University · KRChungbuk National University · KRSungkyunkwan University · KRYonsei University · KRAsan Medical Center · KRCatholic University of Korea · KRKorea Advanced Institute of Science and Technology · KRKyungpook National University · KRSejong General Hospital · KRSeoul National University Bundang Hospital · KRUlsan College · KRUniversity of Ulsan · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsThis study investigated the prognostic power of corrected QT (QTc) interval in patients with acute heart failure (AHF) according to sex.

methodsWe analyzed multicenter Korean Acute Heart Failure registry with patients with AHF admitted from 2011 to 2014. Among them, we analyzed 4,990 patients who were followed up to 5 years. Regarding QTc interval based on 12 lead electrocardiogram, patients were classified into quartiles according to sex.

resultsDuring follow-up with median 43.7 months, 2,243 (44.9%) patients died. The relationship between corrected QT interval and all-cause mortality followed a J-curve relationship. In Kaplan-Meier analysis, both sex had lowest mortality in the second QTc quartile. There were significant prognostic differences between the second and the fourth quartiles in male (log-rank p = 0.002), but not in female (log-rank p = 0.338). After adjusting covariates, the third (hazard ratio [HR], 1.185; 95% confidence interval [CI], 1.001 to 1.404; p = 0.049) and the fourth (HR, 1.404; 95% CI, 1.091 to 1.535; p = 0.003) quartiles demonstrated increased risk of mortality compared to the second quartile in male. In female, however, there was no significant difference across quartiles. QTc interval was associated with 5-year all-cause mortality in J-shape with nadir of 440 to 450 ms in male and 470 to 480 ms in female.

conclusionQTc interval was an independent predictor of overall death in male, but its significance decreased in female. The relationship between QTc interval and all-cause mortality was J-shaped in both sex.

Indexed as

Alcohol DrinkingHeart FailureAgedElectrocardiographyFemaleHeart RateHumansMaleMiddle AgedPrognosisProportional Hazards ModelsRisk FactorsHeart failureMortalityPrognosisQTc intervalSex

Identifiers

PMID32380800
PMCPMC7652667
OpenAlexW3022117646

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.