Evidence map›Paper›PMID 32380794›Full record

ArticleCells2020

Regulation of TMEM16A by CK2 and Its Role in Cellular Proliferation.

Madalena C Pinto, Rainer Schreiber, Joana Lerias, Jiraporn Ousingsawat, Aires Duarte, Margarida Amaral, Karl Kunzelmann

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Role of ANO1 in tumors and tumor immunity.Journal of cancer research and clinical oncology · 2022
    Review
  7. Article
  8. The diverse roles of TMEM16A CaJournal of advanced research · 2021
    Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Madalena C PintoFaculty of Sciences, University of Lisbon, BioISI-Biosystems & Integrative Sciences Institute, Campo Grande, 1749-016 Lisbon, Portugal.ORCID 0000-0001-9045-269X
Rainer SchreiberPhysiological Institute, University of Regensburg, University Street 31, D-93053 Regensburg, Germany.
Joana LeriasFaculty of Sciences, University of Lisbon, BioISI-Biosystems & Integrative Sciences Institute, Campo Grande, 1749-016 Lisbon, Portugal.
Jiraporn OusingsawatPhysiological Institute, University of Regensburg, University Street 31, D-93053 Regensburg, Germany.
Aires DuarteFaculty of Sciences, University of Lisbon, BioISI-Biosystems & Integrative Sciences Institute, Campo Grande, 1749-016 Lisbon, Portugal.
Margarida AmaralFaculty of Sciences, University of Lisbon, BioISI-Biosystems & Integrative Sciences Institute, Campo Grande, 1749-016 Lisbon, Portugal.
Karl KunzelmannPhysiological Institute, University of Regensburg, University Street 31, D-93053 Regensburg, Germany.ORCID 0000-0001-6222-4593
University of Lisbon · PTUniversity of Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Casein kinase 2 (CK2) is a highly ubiquitous and conserved serine/threonine kinase that forms a tetramer consisting of a catalytic subunit (CK2α) and a regulatory subunit (CK2β). Despite being ubiquitous, CK2 is commonly found at higher expression levels in cancer cells, where it inhibits apoptosis, and supports cell migration and proliferation. The Ca

Indexed as

Anoctamin-1CalciumCalcium SignalingCasein Kinase IICell LineCell MembraneCell ProliferationEpithelial CellsGene Knockdown TechniquesHumansLungNeoplasm ProteinsProtein Kinase InhibitorsANO1 protein, humanAnoctamin-1CalciumCasein Kinase IINeoplasm ProteinsProtein Kinase Inhibitorsanoctamin 1Ca2+ activated Cl- channelcancerCasein kinase 2CK2proliferationTMEM16A

Identifiers

PMID32380794
PMCPMC7291285
OpenAlexW3023052387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.