Evidence map›Paper›PMID 32380762›Full record

ArticleAntioxidants (Basel, Switzerland)2020

Dual SMO/BRAF Inhibition by Flavonolignans from

Antonia Diukendjieva, Maya M Zaharieva, Mattia Mori, Petko Alov, Ivanka Tsakovska, Tania Pencheva, Hristo Najdenski, Vladimír Křen, Chiara Felici, Francesca Bufalieri and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  7. Importance of glutamine 189 flexibility in SARS-CoV-2 main protease: Lesson learned from in silico virtual screening of ChEMBL database and molecular dynamics.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2021
    Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Antonia DiukendjievaDepartment of QSAR and Molecular Modelling, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0003-3159-9872
Maya M ZaharievaDepartment of Infectious Microbiology, Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Mattia MoriDepartment of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022, University of Siena, 53100 Siena, Italy.ORCID 0000-0003-2398-1254
Petko AlovDepartment of QSAR and Molecular Modelling, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Ivanka TsakovskaDepartment of QSAR and Molecular Modelling, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0003-1389-1685
Tania PenchevaDepartment of QSAR and Molecular Modelling, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0002-1439-8895
Hristo NajdenskiDepartment of Infectious Microbiology, Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.
Vladimír KřenLaboratory of Biotransformation, Institute of Microbiology of the Czech Academy of Sciences, 14220 Prague, Czech Republic.ORCID 0000-0002-1091-4020
Chiara FeliciDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Francesca BufalieriDepartment of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0002-9571-318X
Lucia Di MarcotullioDepartment of Molecular Medicine, Laboratory Affiliated to Istituto Pasteur Italia Fondazione Cenci Bolognetti, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-0274-7178
Bruno BottaDepartment of Chemistry and Technology of Drugs, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-8707-4333
Maurizio BottaDepartment of Biotechnology, Chemistry and Pharmacy, Department of Excellence 2018-2022, University of Siena, 53100 Siena, Italy.
Ilza PajevaDepartment of QSAR and Molecular Modelling, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.ORCID 0000-0001-5412-1586
Bulgarian Academy of Sciences · BGSapienza University of Rome · ITUniversity of Siena · ITCzech Academy of Sciences · CZIstituto Pasteur · IT

Funding

Associazione Italiana Ricerca Cancro (AIRC) #IG20801 to Lucia Di MarcotullioBulgarian Ministry of Education and Science, National Research Program "Healthy Foods for a Strong Bio-Economy and Quality of Life" DCM#577/17.08.2018COST Action CM 1407 "Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery" STSM grant to Antonia DiukendjievaCzech Science Foundation 18-00150S to Vladimir Kren
6 · The paper itself

Abstract

Silymarin is the standardized extract from the fruits of

Indexed as

BRAF kinasecytotoxicityin silico methodssilybinsSmoothened

Identifiers

PMID32380762
PMCPMC7278695
OpenAlexW3022219035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.