Evidence map›Paper›PMID 32380725›Full record

ArticleMolecules (Basel, Switzerland)2020

A One-Pot Divergent Sequence to Pyrazole and Quinoline Derivatives.

Guido Gambacorta, David C Apperley, Ian R Baxendale

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Guido GambacortaDepartment of Chemistry, University of Durham, South Road Durham DH1 3LE, UK.
David C ApperleyDepartment of Chemistry, University of Durham, South Road Durham DH1 3LE, UK.ORCID 0000-0001-7102-0314
Ian R BaxendaleDepartment of Chemistry, University of Durham, South Road Durham DH1 3LE, UK.ORCID 0000-0003-1297-1552

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hydroxy-pyrazole and 3-hydroxy-oxindole motifs have been utilised in several pharma and agrochemical leads but are distinctly underrepresented in the scientific literature due to the limited routes of preparation. We have developed a one-pot procedure for their synthesis starting from simple isatins. The method employs cheap and easy-to-handle building blocks and allows easy isolation.

Indexed as

IsatinMolecular ConformationMolecular StructurePyrazolesQuinolinesIsatinPyrazolesQuinolines15N-MASNMRisatinKnorr pyrazole synthesisoxindolePfitzinger reactionpyrazolequinoline

Identifiers

PMID32380725
PMCPMC7249113

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.