Evidence map›Paper›PMID 32380717›Full record

ArticleViruses2020

Asian Zika Virus Isolate Significantly Changes the Transcriptional Profile and Alternative RNA Splicing Events in a Neuroblastoma Cell Line.

Gaston Bonenfant, Ryan Meng, Carl Shotwell, Pheonah Badu, Anne F Payne, Alexander T Ciota, Morgan A Sammons, J Andrew Berglund, Cara T Pager

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Viral Modulation of Host Splicing.Annual review of virology · 2025
    Review
  4. Article
  5. Review
  6. Subgenomic flaviviral RNAs and human proteins:Computational and structural biotechnology journal · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Gaston BonenfantDepartment of Biological Sciences, University at Albany-SUNY, Albany, NY 12222, USA.
Ryan MengThe RNA Institute, University at Albany-SUNY, Albany, NY 12222, USA.
Carl ShotwellThe RNA Institute, University at Albany-SUNY, Albany, NY 12222, USA.ORCID 0000-0001-7877-2092
Pheonah BaduDepartment of Biological Sciences, University at Albany-SUNY, Albany, NY 12222, USA.
Anne F PayneWadsworth Center, New York State Department of Health (NYSDOH), Slingerlands, NY 12159, USA.
Alexander T CiotaWadsworth Center, New York State Department of Health (NYSDOH), Slingerlands, NY 12159, USA.
Morgan A SammonsDepartment of Biological Sciences, University at Albany-SUNY, Albany, NY 12222, USA.
J Andrew BerglundDepartment of Biological Sciences, University at Albany-SUNY, Albany, NY 12222, USA.ORCID 0000-0002-5198-2724
Cara T PagerDepartment of Biological Sciences, University at Albany-SUNY, Albany, NY 12222, USA.ORCID 0000-0003-2024-3782
University at Albany, State University of New York · USNew York State Department of Health · USUniversity of Florida · US

Funding

Determining the factors that control dose-dependent splicing regulation by a master regulatorR01GM121862 · NIGMS · UNIVERSITY OF FLORIDA · PI BERGLUND, ANDREW, SPITALE, ROBERT C · 2017 to 2020
$2.0M
Modulation of RNA modifications by RNA virusesR01GM123050 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI FABRIS, DANIELE, PAGER, CARA THERESIA · 2018 to 2021
$1.9M
Role of Post-transcription RNA Modifications on Zika Virus Gene ExpressionR21AI133617 · NIAID · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI FABRIS, DANIELE, PAGER, CARA THERESIA · 2017 to 2018
$486k
NIAID NIH HHS R21 AI133617NIGMS NIH HHS R01 GM123050NIH HHS R01 GM121862
6 · The paper itself

Abstract

The alternative splicing of pre-mRNAs expands a single genetic blueprint to encode multiple, functionally diverse protein isoforms. Viruses have previously been shown to interact with, depend on, and alter host splicing machinery. The consequences, however, incited by viral infection on the global alternative slicing (AS) landscape are under-appreciated. Here, we investigated the transcriptional and alternative splicing profile of neuronal cells infected with a contemporary Puerto Rican Zika virus (ZIKV

Indexed as

Alternative SplicingAsiaCell Line, TumorHumansNeuroblastomaTranscription, GeneticZika VirusZika Virus Infectionalternative splicingFlavivirusSH-SY5YtranscriptomeZika virus

Identifiers

PMID32380717
PMCPMC7290316
OpenAlexW3021497378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.