Trial reportNutrients2020
The Effect of Parenteral or Oral Iron Supplementation on Fatigue, Sleep, Quality of Life and Restless Legs Syndrome in Iron-Deficient Blood Donors: A Secondary Analysis of the IronWoMan RCT.
Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01787526 (High Dose Intravenous Iron in Blood Donors With Iron Deficiency), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
High Dose Intravenous Iron in Blood Donors With Iron Deficiency: a Randomized, Controlled Trial
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Prevalence of restless legs syndrome in Pakistan: a systematic review and meta-analysis across diverse study populations.BMC neurology · 2026Pooled it
- Latent iron deficiency as a silent driver of donor attrition in high-frequency plateletpheresis donors: a longitudinal cohort study.Annals of hematology · 2026Article
- Sex-Specific Differences in Dietary Iron Intake and Sleep Disorder in NHANES 2005-2014 Population.Food science & nutrition · 2026Article
- Associations between essential trace elements and sleep quality in Iranian adults based on the Pittsburgh Sleep Quality Index.Scientific reports · 2025Article
- Review
- Review
- Designing and Developing a Vision-Based System to Investigate the Emotional Effects of News on Short Sleep at Noon: An Experimental Case Study.Sensors (Basel, Switzerland) · 2023Article
- Pilot Study to Gain First Indications for the Impact of a 3-Month's Oral Intake of a Sucrosomial Iron Supplement on Hemoglobin in Iron-Deficient Blood Donors.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Article
- Article
- Association of Anemia with Clinical Symptoms Commonly Attributed to Anemia-Analysis of Two Population-Based Cohorts.Journal of clinical medicine · 2023Article
- Anemia in pregnancy and sleep of 6-month-old infants: A prospective cohort study.Frontiers in nutrition · 2023Article
- Headache as a Neurologic Manifestation of Systemic Disease.Current treatment options in neurology · 2022Review
- Iron Deficiency and Blood Donation: Links, Risks and Management.Journal of blood medicine · 2022Review
- Peripheral Iron Metabolism is Associated with Leg Movements on Polysomnography but Not with the Severity of Restless Legs Syndrome or Its Impact on Patients.Nature and science of sleep · 2022Article
- Review
- Ethical Issues and Management of Fetal Hemolytic Anemia Caused by Anti-Rh17 in a Multipara with Rare -D- Phenotype.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2021Article
- Association of proton pump inhibitor and histamine H2-receptor antagonists with restless legs syndrome.Sleep · 2021Observational
- The Association of Self-Reported Iron and Vitamin D Levels on Sleep Quality and Pain Perception in a Subset of Saudi Population.Risk management and healthcare policy · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
METHODS/
designProspective, randomized, controlled, single-centre trial. (ClinicalTrials.gov: NCT01787526).
settingTertiary care center in Graz, Austria.
participants176 (138 female and 38 male) whole-blood and platelet apheresis donors aged ≥ 18 and ≤ 65 years with iron deficiency (ferritin ≤ 30ng/mL at the time of blood donation).
interventionsIntravenous iron (1 g ferric carboxymaltose, n = 86) or oral iron supplementation (10 g iron fumarate, 100 capsules, n = 90). MEASUREMENTS: Clinical symptoms were evaluated by a survey before iron therapy (visit 0, V0) and after 8-12 weeks (visit 1, V1), including questions about symptoms of restless legs syndrome (RLS), chronic fatigue syndrome (CFS), sleeping disorders, quality of life and symptoms like headaches, dyspnoea, dizziness, palpitations, pica and trophic changes in fingernails or hair.
resultsWe found a significant improvement in the severity of symptoms for RLS, fatigue and sleep quality (
conclusionIron supplementation in iron-deficient blood donors may be an effective strategy to improve symptoms related to iron deficiency and the wellbeing of blood donors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.