Evidence map›Paper›PMID 32380648›Full record

ArticleNutrients2020

Prophylactic Intra-Uterine β-Cyclodextrin Administration during Intra-Uterine

Cathelijne Heymans, Lara R Heij, Kaatje Lenaerts, Marcel den Dulk, Mhamed Hadfoune, Chantal van Heugten, Owen B Spiller, Michael L Beeton, Sarah J Stock, Alan H Jobe and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 5 countries.

Cathelijne HeymansDepartment of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands.ORCID 0000-0001-9373-1360
Lara R HeijDepartment of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands.ORCID 0000-0002-0602-3356
Kaatje LenaertsDepartment of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands.
Marcel den DulkDepartment of Surgery, University Hospital Aachen, 52074 Aachen, Germany.
Mhamed HadfouneDepartment of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands.
Chantal van HeugtenDepartment of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands.
Owen B SpillerDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF10 3AT, UK.ORCID 0000-0002-9117-6911
Michael L BeetonCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff CF5 2YB, UK.
Sarah J StockUsher Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK.
Alan H JobeDivision of Obstetrics and Gynecology, The University of Western Australia, Crawley WA 6009, Australia.
Matthew S PayneDivision of Obstetrics and Gynecology, The University of Western Australia, Crawley WA 6009, Australia.
Matthew W KempDivision of Obstetrics and Gynecology, The University of Western Australia, Crawley WA 6009, Australia.
Boris W KramerDepartment of Pediatrics, School for Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands.
Jogchum PlatDepartment of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands.
Wim G van GemertDepartment of Surgery, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands.
Tim G A M WolfsDepartment of Pediatrics, School for Oncology and Developmental Biology (GROW), Maastricht University, 6200 MD Maastricht, The Netherlands.ORCID 0000-0003-4417-4144
Maastricht University · NLUniversity Medical Center · USCardiff Metropolitan University · GBCardiff University · GBCincinnati Children's Hospital Medical Center · USMurdoch University · AUThe University of Western Australia · AUUniversity of Edinburgh · GB

Funding

Kinderonderzoekfonds Limburg N.A.
6 · The paper itself

Abstract

Chorioamnionitis can lead to inflammation and injury of the liver and gut, thereby predisposing patients to adverse outcomes such as necrotizing enterocolitis (NEC). In addition, intestinal bile acids (BAs) accumulation is causally linked to NEC development. Plant sterols are a promising intervention to prevent NEC development, considering their anti-inflammatory properties in the liver. Therefore, we investigated whether an intra-amniotic (IA)

Indexed as

beta-CyclodextrinsDrug CarriersPhytotherapyUreaplasmaUreaplasma InfectionsAnimalsCholesterolChorioamnionitisDisease Models, AnimalEnterocolitis, NecrotizingEnterohepatic CirculationFemaleFetusInflammationInjections, IntralesionalLiverbeta-CyclodextrinsbetadexcampesterolCholesterolDrug Carriersgamma-sitosterolPhytosterolsSitosterolschorioamnionitisenterohepatic circulationintra-uterine infectionliverplant sterolspreterm birthsheepUreaplasma parvum

Identifiers

PMID32380648
PMCPMC7284867
OpenAlexW3022050991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.