ArticleJournal of neurogastroenterology and motility2020
Prevalence of Disaccharidase Deficiency in Adults With Unexplained Gastrointestinal Symptoms.
Article in Journal of neurogastroenterology and motility, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Disaccharidase testing and clinical outcomes: a retrospective study.Proceedings (Baylor University. Medical Center) · 2026Article
- Disaccharidase testing in adults: do we need new testing standards?Proceedings (Baylor University. Medical Center) · 2026Article
- Little Patients Big Discoveries: Potential Pediatric to Adult Neurogastroenterology Translation.The American journal of gastroenterology · 2025Review
- Disaccharidase Enzyme Deficiency in Adult Patients With Gas and Bloating.Clinical and translational gastroenterology · 2025Article
- Adult-Onset Autoimmune Enteropathy Mimicking Disaccharidase Deficiency.Gastroenterology research · 2024Article
- Intestinal Disaccharidase Deficiency in Adults: Evaluation and Treatment.Current gastroenterology reports · 2023Review
- AGA-PancreasFest Joint Symposium on Exocrine Pancreatic Insufficiency.Gastro hep advances · 2023Review
- Sucrose intolerance in adults with common functional gastrointestinal symptoms.Proceedings (Baylor University. Medical Center) · 2022Article
- Patients with functional bowel disorder have disaccharidase deficiency: A single-center study from Russia.World journal of clinical cases · 2021Article
- Review
- Disaccharidase Deficiency as a Cause of Unexplained Functional Gastrointestinal Disorder.Journal of neurogastroenterology and motility · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Aims: Disaccharidase assay is used for assessing carbohydrate intolerance in children, but its usefulness in adults is not known. The aim of this study is to assess the prevalence of disaccharidase deficiency in patients with unexplained gastrointestinal symptoms. Methods: A retrospective review of adults with chronic (> 1 year) abdominal symptoms and negative imaging and endoscopy/colonoscopy and who completed bowel symptom questionnaire and duodenal biopsy for lactase, maltase, sucrase, and palatinase was performed. A subset also underwent 25 g lactose breath test (LBT). Results: One hundred twenty patients (females = 83) were evaluated, of whom 48 also underwent LBT. Fifty-six (46.7%) patients had enzyme deficiency; 44 (36.7%) had single (either lactase or maltase), 1 had 3 enzyme deficiencies, 11 (9.2 %) had all 4 disaccharidase enzyme (pan-disaccharidase) deficiency, and 64 (53.0%) had normal enzyme levels. Baseline prevalence and severity of 11 gastrointestinal symptoms were similar between normal and single enzyme deficiency groups. The sensitivity and specificity of LBT was 78.3% and 72.0%, respectively and overall agreement with lactase deficiency was 75.0%. Conclusions: Isolated disaccharidase deficiency occurs in adults, usually lactase and rarely maltase, and pan-disaccharidase deficiency is rare. Baseline symptoms or its severity did not predict enzyme deficiency.
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