Evidence map›Paper›PMID 32380507›Full record

Observational studyPediatric research2021

Effect on splanchnic oxygenation of breast milk, fortified breast milk, and formula milk in preterm infants.

Carlo Dani, Caterina Coviello, Simona Montano, Giulia Remaschi, Chiara Petrolini, Maria Chiara Strozzi, Elena Maggiora, Miriam Sabatini, Diego Gazzolo

Erratum issued Registry-linked trialAbstract readComparative StudyMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05888090 (The Effect of Position Given to Preterms After Feeding on Gastric Residual Volume, Abdominal Oxygenation and Fractional Oxygen Extraction), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05888090 nacompletednot on this mapstarted 2023, after this paper: background citation

The Effect of Position Given to Preterms After Feeding on Gastric Residual Volume, Abdominal Oxygenation and Fractional Oxygen Extraction

TypeinterventionalSponsorIstanbul University - CerrahpasaRan2023 to 2025Enrolled48ConditionsGastric Residual Volume, Abdominal Oxygenation, Fractional Oxygen Extraction, Positioning (Prone, Right Lateral and Semi-Elevated Supine Position)ArmsProne, right lateral, and semi-elevated supine positions, Semi-elevated supine, prone, and right lateral positions, Right lateral, semi-elevated supine, and prone positions
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. The fifty billion dollar question: does formula cause necrotizing enterocolitis?Journal of perinatology : official journal of the California Perinatal Association · 2025
    Review
  3. Observational
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Carlo DaniDivision of Neonatology, Careggi University Hospital of Florence, Florence, Italy. cdani@unifi.It.
Caterina CovielloDepartment of Neurosciences, Psychology, Drug Research, and Child Health, University of Florence, Florence, Italy.
Simona MontanoDepartment of Neurosciences, Psychology, Drug Research, and Child Health, University of Florence, Florence, Italy.
Giulia RemaschiDepartment of Neurosciences, Psychology, Drug Research, and Child Health, University of Florence, Florence, Italy.
Chiara PetroliniDepartment of Neurosciences, Psychology, Drug Research, and Child Health, University of Florence, Florence, Italy.
Maria Chiara StrozziAO SS Antonio, Biagio and C. Arrigo Hospital, Alessandria, Italy.
Elena MaggioraAO SS Antonio, Biagio and C. Arrigo Hospital, Alessandria, Italy.
Miriam SabatiniAO SS Antonio, Biagio and C. Arrigo Hospital, Alessandria, Italy.
Diego GazzoloNeonatal Intensive Care Unit G. D'Annunzio University of Chieti, Chieti, Italy.
University of Florence · ITAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITAzienda Ospedaliero-Universitaria Careggi · ITUniversity of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEnteral feeding induces mesenteric hemodynamic changes in preterm infants, which may vary according to the milk used. Our aim in this study was to evaluate changes of splanchnic regional oxygenation (rSO

methodsInfants born at 25-31 weeks of gestational age (n = 54) received a bolus of MOM, FHM, or PTF. rSO

resultsIn the MOM group, rSO

conclusionsSplanchnic oxygenation was not affected by MOM feeding, was transiently decreased by FBM feeding, and was persistently decreased by PTF. These results suggest that preterm infants who received PTF has higher splanchnic tissue oxygen extraction compared to those who received MOM or FBM. IMPACT: Human milk feeding is associated to a lower splanchnic energy expenditure than preterm formula feeding. Fortified human milk transiently increases splanchnic energy expenditure. Preterm formula should be used only in the absence of human milk.

Indexed as

Bottle FeedingBreast FeedingFood, FortifiedInfant FormulaInfant, PrematureMilk, HumanSplanchnic CirculationEnergy MetabolismGestational AgeHumansInfant, NewbornItalyOximetryOxygenProspective StudiesSpectroscopy, Near-InfraredOxygen

Identifiers

PMID32380507
OpenAlexW3023188300

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.