Evidence map›Paper›PMID 32380448›Full record

ArticleBrain stimulation

Stimulus frequency modulates brainstem response to respiratory-gated transcutaneous auricular vagus nerve stimulation.

Roberta Sclocco, Ronald G Garcia, Norman W Kettner, Harrison P Fisher, Kylie Isenburg, Maya Makarovsky, Jessica A Stowell, Jill Goldstein, Riccardo Barbieri, Vitaly Napadow

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 3 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 129 citations in OpenAlex.

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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Roberta ScloccoAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Department of Radiology, Logan University, Chesterfield, MO, USA. Electronic address: roberta@nmr.mgh.harvard.edu.
Ronald G GarciaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; School of Medicine, Universidad de Santander (UDES), Bucaramanga, Colombia.
Norman W KettnerDepartment of Radiology, Logan University, Chesterfield, MO, USA.
Harrison P FisherAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Kylie IsenburgAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Maya MakarovskyAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Jessica A StowellDepartment of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Jill GoldsteinAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Riccardo BarbieriDepartment of Electronics, Information and Bioengineering, Politecnico di Milano, Italy; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Vitaly NapadowAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Department of Radiology, Logan University, Chesterfield, MO, USA.
Harvard University · USLogan University · US

Funding

Core NIBSP01AT009965 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI NAPADOW, VITALY, ROSEN, BRUCE R · 2018 to 2023
$10.9M
The Role of Context Effect in Acupuncture Treatment of Low Back/J.KongP01AT006663 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI HIRSCHTICK, RANDY L, ROSEN, BRUCE R · 2011 to 2017
$10.0M
Project 4P41EB015896 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 2012 to 2018
$9.8M
Brain Mechanisms Underlying CBT-Related Reductions in FibromyalgiaR01AR064367 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI EDWARDS, ROBERT R, NAPADOW, VITALY · 2014 to 2018
$4.0M
Neuroimaging Approaches to Deconstructing Acupuncuture for Chronic PainR01AT007550 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HARRIS, RICHARD E, NAPADOW, VITALY · 2013 to 2019
$3.4M
Mapping the linkage between auricular vagus nerve receptors and cardiovagal modulationOT2OD023867 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI NAPADOW, VITALY · 2016 to 2021
$3.4M
Optimization of brain-based mechanisms supporting psychosocial aspects of acupuncture therapy - a hyperscanning fMRI studyR33AT009306 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KAPTCHUK, TED, NAPADOW, VITALY · 2018 to 2021
$2.3M
SILICON GRAPHICS PRISM EXTREME 128P/1TBS10RR023043 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$1.5M
Optimization of brain-based mechanisms supporting psychosocial aspects of acupuncture therapy - a hyperscanning fMRI studyR61AT009306 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI KAPTCHUK, TED, NAPADOW, VITALY · 2016 to 2017
$959k
Neuromodulation of the Brain-Gut Axis by Transcutaneous Vagal Nerve Stimulation in Functional DyspepsiaR21DK116029 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI NAPADOW, VITALY · 2018 to 2019
$463k
NCCIH NIH HHS P01 AT006663NCCIH NIH HHS P01 AT009965NCCIH NIH HHS R01 AT007550NCCIH NIH HHS R33 AT009306NCCIH NIH HHS R61 AT009306NCRR NIH HHS S10 RR023043NIAMS NIH HHS R01 AR064367NIBIB NIH HHS P41 EB015896NIDDK NIH HHS R21 DK116029NIH HHS OT2 OD023867
6 · The paper itself

Abstract

backgroundThe therapeutic potential of transcutaneous auricular VNS (taVNS) is currently being explored for numerous clinical applications. However, optimized response for different clinical indications may depend on specific neuromodulation parameters, and systematic assessments of their influence are still needed to optimize this promising approach. HYPOTHESIS: We proposed that stimulation frequency would have a significant effect on nucleus tractus solitarii (NTS) functional MRI (fMRI) response to respiratory-gated taVNS (RAVANS).

methodsBrainstem fMRI response to auricular RAVANS (cymba conchae) was assessed for four different stimulation frequencies (2, 10, 25, 100 Hz). Sham (no current) stimulation was used to control for respiration effects on fMRI signal.

resultsOur findings demonstrated that RAVANS delivered at 100 Hz evoked the strongest brainstem response, localized to a cluster in the left (ipsilateral) medulla and consistent with purported NTS. A co-localized, although weaker, response was found for 2 Hz RAVANS. Furthermore, RAVANS delivered at 100 Hz also evoked stronger fMRI responses for important monoamine neurotransmitter source nuclei (LC, noradrenergic; MR, DR, serotonergic) and pain/homeostatic regulation nuclei (i.e. PAG).

conclusionOur fMRI results support previous localization of taVNS afference to pontomedullary aspect of NTS in the human brainstem, and demonstrate the significant influence of the stimulation frequency on brainstem fMRI response.

Indexed as

RespirationBrain StemFemaleHumansMagnetic Resonance ImagingMaleTranscutaneous Electric Nerve StimulationVagus NerveVagus Nerve StimulationfMRILocus CoeruleusMedullaRaphetVNS

Identifiers

PMID32380448
PMCPMC7931850
OpenAlexW3013953363

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.