Evidence map›Paper›PMID 32380308›Full record

ArticleThrombosis research2020

Developing a model for predicting venous thromboembolism in obese pregnant women in a national study.

Julia Ellis-Kahana, Andrew D Sparks, Alexis C Gimovsky, Andra H James, Homa K Ahmadzia

Open access · greenAbstract read
In one paragraph

Article in Thrombosis research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Management of obesity across women's life course: FIGO Best Practice Advice.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2023
    Article
  6. Article
  7. Venous Thromboembolism Risk Factors in Women With Obesity Who Undergo Cesarean Delivery.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Julia Ellis-KahanaGeorge Washington University, School of Medicine and Health Sciences, Department of Obstetrics and Gynecology, Washington, DC, United States of America.
Andrew D SparksGeorge Washington University, School of Medicine and Health Sciences, Department of Obstetrics and Gynecology, Washington, DC, United States of America.
Alexis C GimovskyGeorge Washington University, School of Medicine and Health Sciences, Department of Obstetrics and Gynecology, Washington, DC, United States of America.
Andra H JamesDuke University Medical Center, Department of Obstetrics and Gynecology, Durham, NC, United States of America.
Homa K AhmadziaGeorge Washington University, School of Medicine and Health Sciences, Department of Obstetrics and Gynecology, Washington, DC, United States of America. Electronic address: hAhmadzia@mfa.gwu.edu.
George Washington University · USDuke Medical Center · US

Funding

Prevention of postpartum hemorrhage: identifying pregnant women at risk and determining the safe and effective use of tranexamic acid using state-of-the-art pharmacokinetic/pharmacodynamics modelingK23HL141640 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI AHMADZIA, HOMA KHORRAMI · 2019 to 2022
$621k
NHLBI NIH HHS K23 HL141640
6 · The paper itself

Abstract

introductionVenous thromboembolism (VTE) in pregnancy and postpartum is a leading cause of maternal morbidity and mortality in developed countries, where obesity is a known risk for this complication. Current guidelines vary in which patients qualify for VTE prophylaxis, precluding a uniform approach for management. We sought to derive a risk prediction model for VTE in obese pregnant women. MATERIALS AND

methodsWe performed a retrospective cohort analysis using the Consortium on Safe Labor (CSL) database. Women ages 16-45 who were pregnant with singletons and had an obese body mass index (>30 kg/m

resultsOf the 83,500 women who met inclusion criteria, on average women were 27.8 years old, 38.6 weeks gestation, with body mass index of 35.8, and cesarean delivery incidence of 35.2%. 109 women (0.13%) experienced a VTE event. Independent predictors of VTE in our final multivariable predictive model included: mode of delivery, body mass index, pregestational diabetes, chronic heart disease, preeclampsia, blood transfusion (intrapartum or postpartum), prenatal history of thromboembolic disorder, and postpartum maternal length of stay. A receiver operating characteristic curve was developed to assess the model; area under the curve was 0.826.

conclusionsWe developed a strong predictive model using a large, retrospective database to distinguish risk of VTE in obese pregnant women, which may provide the foundation for future protocol development of obstetrical thromboprophylaxis in obese women.

Indexed as

ObesityPregnancy Complications, HematologicVenous ThromboembolismAdolescentAdultAnticoagulantsFemaleHumansMiddle AgedModels, TheoreticalPregnancyRetrospective StudiesRisk FactorsYoung AdultAnticoagulantsLow molecular weight heparinMaternal morbidityObesityPregnancyThromboprophylaxisVenous thromboembolism

Identifiers

PMID32380308
PMCPMC7298727
OpenAlexW3019338565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.