Evidence map›Paper›PMID 32380274›Full record

ArticleBrain, behavior, and immunity2020

Modulation of fear behavior and neuroimmune alterations in house dust mite exposed A/J mice, a model of severe asthma.

I Lewkowich, R Ahlbrand, E Johnson, J McAlees, N Nawreen, R Raman, I Lingel, J Hargis, C Hoover, R Sah

Open access · greenAbstract read
In one paragraph

Article in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. The emerging role of T cells in depression.Frontiers in psychiatry · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Systemic Inflammation in Asthma: What Are the Risks and Impacts Outside the Airway?The journal of allergy and clinical immunology. In practice · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

I LewkowichDivision of Immunobiology, Children's Hospital Medical Center, Cincinnati, OH 45220, United States; Department of Pediatrics, University of Cincinnati, Cincinnati, OH 45220, United States.
R AhlbrandDept. of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, OH 45220, United States.
E JohnsonDept. of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, OH 45220, United States; Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45220, United States.
J McAleesDivision of Immunobiology, Children's Hospital Medical Center, Cincinnati, OH 45220, United States.
N NawreenNeuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45220, United States.
R RamanDept. of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, OH 45220, United States.
I LingelDivision of Immunobiology, Children's Hospital Medical Center, Cincinnati, OH 45220, United States.
J HargisDivision of Immunobiology, Children's Hospital Medical Center, Cincinnati, OH 45220, United States.
C HooverNeuroscience Undergraduate Program, University of Cincinnati, Cincinnati, OH 45220, United States.
R SahDept. of Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, OH 45220, United States; Neuroscience Graduate Program, University of Cincinnati, Cincinnati, OH 45220, United States; VA Medical Center, Cincinnati, OH 45220, United States. Electronic address: sahr@uc.edu.
University of Cincinnati · USCincinnati Children's Hospital Medical Center · US

Funding

PREDOCTORAL TRAINING PROGRAM IN THE NEUROSCIENCEST32NS007453 · NINDS · UNIVERSITY OF CINCINNATI · PI HERMAN, JAMES P · 1997 to 2025
$4.0M
Neuroimmune modulators of airway inflammation associated stress and fear responsesR21MH117483 · NIMH · UNIVERSITY OF CINCINNATI · PI LEWKOWICH, IAN PAUL, SAH, RENU · 2019 to 2020
$455k
NIMH NIH HHS R21 MH117483NINDS NIH HHS T32 NS007453
6 · The paper itself

Abstract

Fear-associated conditions such as posttraumatic stress disorder (PTSD) and panic disorder (PD) are highly prevalent. There is considerable interest in understanding contributory risk and vulnerability factors. Accumulating evidence suggests that chronically elevated inflammatory load may be a potential risk factor for these disorders. In this regard, an association of asthma, a chronic inflammatory condition, with PTSD and PD has been reported. Symptoms of PD and PTSD are more prevalent in severe asthmatics, compared to those with mild or moderate asthma suggesting that factors that influence the severity of asthma, may also influence susceptibility to the development of fear-related disorders. There has been relatively little progress in identifying contributory factors and underlying mechanisms, particularly, the translation of severe asthma-associated lung inflammation to central neuroimmune alterations and behavioral manifestations remains unclear. The current study investigated the expression of behaviors relevant to PD and PTSD (CO

Indexed as

AsthmaFearAnimalsDisease Models, AnimalExtinction, PsychologicalMicePyroglyphidaeSeverity of Illness IndexTh2 CellsAsthmaFearIL-17ANeuroimmunePTSDTh17

Identifiers

PMID32380274
PMCPMC8988097
OpenAlexW3022989381

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.