Evidence map›Paper›PMID 32380253›Full record

ReviewJournal of sport and health science2020

Exercise-induced oxidative stress: Friend or foe?

Scott K Powers, Rafael Deminice, Mustafa Ozdemir, Toshinori Yoshihara, Matthew P Bomkamp, Hayden Hyatt

2 registry-linked trialsOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of sport and health science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 367 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
367citing papers in PubMed, 12 pooled it
37.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05592509 nacompletednot on this mapstarted 2022, after this paper: background citation

Evaluation of the Antioxidant Effect of a Mixture of Ozonated Vegetable Oil and Vitamin Complex (Vitamin K2 and Vitamin B9) in Moderately Active Subjects With "Physical Activity Level" (LAF: 1.70-1.99): Pilot Study

TypeinterventionalSponsorS&R Farmaceutici S.p.A.Ran2022 to 2023Enrolled20ConditionsOxidative Stress, InflammationArmsOzonized vegetable oil with vitamines
NCT07728422 nacompletednot on this mapstarted 2024, after this paper: background citation

Effects of Ozone Therapy Modalities on Biochemical Markers of Muscle Damage Following Eccentric Exercise

TypeinterventionalSponsorInonu UniversityRan2024 to 2025Enrolled32ConditionsOzone Therapy, Muscle Damage, Oxidative Stress, RecoveryArmsAutohemotherapy, Ozone Sauna Therapy, Ozonated Lavender Oil Massage
3 · Its place in the literature

Who cites it

367 citing papers in PubMed, 12 syntheses or guidelines pooled it, 604 citations in OpenAlex.

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307 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 4 countries.

Scott K PowersDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32608, USA.
Rafael DeminiceDepartment of Physical Education, State University of Londrina, Londrina, 10011, Brazil.
Mustafa OzdemirDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32608, USA; Department of Exercise and Sport Sciences, Hacettepe University, Ankara, 06800, Turkey. Electronic address: ozdemirm@ufl.edu.
Toshinori YoshiharaDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32608, USA; Department of Exercise Physiology, Juntendo University, Tokyo, 270-1695, Japan.
Matthew P BomkampDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32608, USA.
Hayden HyattDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, 32608, USA.
University of Florida · USHacettepe University · TRUniversidade Estadual de Londrina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The first report demonstrating that prolonged endurance exercise promotes oxidative stress in humans was published more than 4 decades ago. Since this discovery, many ensuing investigations have corroborated the fact that muscular exercise increases the production of reactive oxygen species (ROS) and results in oxidative stress in numerous tissues including blood and skeletal muscles. Although several tissues may contribute to exercise-induced ROS production, it is predicted that muscular contractions stimulate ROS production in active muscle fibers and that skeletal muscle is a primary source of ROS production during exercise. This contraction-induced ROS generation is associated with (1) oxidant damage in several tissues (e.g., increased protein oxidation and lipid peroxidation), (2) accelerated muscle fatigue, and (3) activation of biochemical signaling pathways that contribute to exercise-induced adaptation in the contracting muscle fibers. While our understanding of exercise and oxidative stress has advanced rapidly during the last decades, questions remain about whether exercise-induced increases in ROS production are beneficial or harmful to health. This review addresses this issue by discussing the site(s) of oxidant production during exercise and detailing the health consequences of exercise-induced ROS production.

Indexed as

Oxidative StressAdaptation, PhysiologicalAnimalsAntioxidantsExerciseHumansMuscle ContractionMuscle FatigueMuscle Fibers, SkeletalMuscle, SkeletalOxidation-ReductionReactive Oxygen SpeciesAntioxidantsReactive Oxygen SpeciesHormesisOxidantsRadicalsReactive oxygen speciesSkeletal muscle

Identifiers

PMID32380253
PMCPMC7498668
OpenAlexW3022014008

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.