Evidence map›Paper›PMID 32380229›Full record

ArticleThe Canadian journal of cardiology2021

Cardiovascular Risk Factors and Perioperative Myocardial Infarction After Noncardiac Surgery.

Tanya Wilcox, Nathaniel R Smilowitz, Yuhe Xia, Joshua A Beckman, Jeffrey S Berger

Open access · greenAbstract read
In one paragraph

Article in The Canadian journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Perioperative Mortality: A Retrospective Cohort Study of 75,446 Noncardiac Surgery Patients.Mayo Clinic proceedings. Innovations, quality & outcomes · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Smoking Cessation for Preoperative Optimization.Clinics in colon and rectal surgery · 2023
    Review
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tanya WilcoxThe Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York, USA.
Nathaniel R SmilowitzThe Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York, USA.
Yuhe XiaThe Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York, USA.
Joshua A BeckmanDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Jeffrey S BergerThe Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York, USA; Department of Surgery, New York University School of Medicine, New York, New York, USA. Electronic address: jeffrey.berger@nyumc.org.
New York University · USVanderbilt University · US

Funding

Training Program in Cardiovascular SciencesT32HL098129 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Glenn I Fishman, Ira J Goldberg · 2009 to 2026
$5.9M
Platelet Activity & Cardiovascular Events following Vascular SurgeryR01HL114978 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BERGER, JEFFREY S · 2013 to 2017
$3.0M
NHLBI NIH HHS R01 HL114978NHLBI NIH HHS T32 HL098129
6 · The paper itself

Abstract

backgroundPerioperative cardiovascular events are a leading cause of morbidity and mortality after noncardiac surgery. We propose a simplified method for perioperative risk stratification.

methodsIn a retrospective cohort study we identified patients who underwent noncardiac surgery between 2009 and 2015 in the US National Surgical Quality Improvement Program. Multivariable logistic regression models adjusted for age, sex, race, and surgery type were generated to estimate the effect of traditional cardiovascular risk factors (hypertension, diabetes mellitus, current smoking) on odds of perioperative myocardial infarction (MI). Time to event analysis was conducted using competing risk analysis, with MI as the outcome event and death as the competing risk.

resultsA total of 3,848,501 noncardiac surgeries were identified. Postoperative MI occurred in 0.37% of patients and 1.04% of patients died. The 30-day event rate of perioperative MI increased in a stepwise fashion with additional risk factors (0.42% for 1, 0.82% for 2, and 1.08% for 3; P for trend < 0.001) after accounting for the competing risk of death. Compared with those with no risk factors, patients with 1, 2, and 3 risk factors had increased odds of MI (adjusted odds ratio [aOR], 2.07 [95% confidence interval (CI), 1.96-2.19]; aOR, 3.63 [95% CI, 3.43-3.85]; and aOR, 5.54 [95% CI, 5.09-6.04], respectively). Perioperative MI was rare (0.10%) in patients without risk factors.

conclusionsPatients with cardiovascular risk factors are at increased risk of perioperative MI, those without risk factors are at low risk. Further evaluation is needed to determine the effect of a simplified risk score in the perioperative setting.

Indexed as

Heart Disease Risk FactorsMyocardial InfarctionPostoperative ComplicationsAgedDiabetes MellitusFemaleGeneral SurgeryHumansHypertensionMaleMiddle AgedMortalityQuality ImprovementRetrospective StudiesRisk AssessmentSmoking

Identifiers

PMID32380229
PMCPMC9960189
OpenAlexW3023571728

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.