ReviewAgeing research reviews2020
Sleep, Noninvasive Brain Stimulation, and the Aging Brain: Challenges and Opportunities.
Review in Ageing research reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Repeated Continuous Theta-Burst Stimulation Modulates Resting-State EEG Microstate Dynamics in Athletes with Chronic Insomnia.Brain sciences · 2026Article
- Potential role of meningeal lymphatic drainage in repetitive transcranial magnetic stimulation-induced cognitive improvement: A call for further research.World journal of psychiatry · 2025Article
- Impact of spindle-inspired transcranial alternating current stimulation during a nap on sleep-dependent motor memory consolidation in healthy older adults.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Exploring Perceptions and Experiences of Patients Undergoing Transcranial Magnetic Stimulation (TMS) for Depression and Adjustment Disorder in Romanian Private Practices.Medicina (Kaunas, Lithuania) · 2025Article
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- Article
- A unique color-coded visualization system with multimodal information fusion and deep learning in a longitudinal study of Alzheimer's disease.Artificial intelligence in medicine · 2023Article
- Targeting neural correlates of placebo effects.Cognitive, affective & behavioral neuroscience · 2023Review
- Optimizing transcranial magnetic stimulation for spaceflight applications.NPJ microgravity · 2023Article
- Circadian disruption and sleep disorders in neurodegeneration.Translational neurodegeneration · 2023Review
- Etiology and Clinical Significance of Network Hyperexcitability in Alzheimer's Disease: Unanswered Questions and Next Steps.Journal of Alzheimer's disease : JAD · 2023Review
- Article
- Tau Toxicity in Neurodegeneration.Molecular neurobiology · 2022Review
- Toward noninvasive brain stimulation 2.0 in Alzheimer's disease.Ageing research reviews · 2022Review
- Alzheimer's disease is an inherent, natural part of human brain aging: an integrated perspective.Free neuropathology · 2022Article
- Sleep EEG-Based Approach to Detect Mild Cognitive Impairment.Frontiers in aging neuroscience · 2022Article
- Sleep-Based Interventions in Alzheimer's Disease: Promising Approaches from Prevention to Treatment along the Disease Trajectory.Pharmaceuticals (Basel, Switzerland) · 2021Review
- MEMS inductor fabrication and emerging applications in power electronics and neurotechnologies.Microsystems & nanoengineering · 2021Review
- Day-to-day sleep efficiency and driving behaviors in older adults with and without cognitive impairment.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
As we age, sleep patterns undergo severe modifications of their micro and macrostructure, with an overall lighter and more fragmented sleep structure. In general, interventions targeting sleep represent an excellent opportunity not only to maintain life quality in the healthy aging population, but also to enhance cognitive performance and, when pathology arises, to potentially prevent/slow down conversion from e.g. Mild Cognitive Impairment (MCI) to Alzheimer's Disease (AD). Sleep abnormalities are, in fact, one of the earliest recognizable biomarkers of dementia, being also partially responsible for a cascade of cortical events that worsen dementia pathophysiology, including impaired clearance systems leading to build-up of extracellular amyloid-β (Aβ) peptide and intracellular hyperphosphorylated tau proteins. In this context, Noninvasive Brain Stimulation (NiBS) techniques, such as transcranial electrical stimulation (tES) and transcranial magnetic stimulation (TMS), may help investigate the neural substrates of sleep, identify sleep-related pathology biomarkers, and ultimately help patients and healthy elderly individuals to restore sleep quality and cognitive performance. However, brain stimulation applications during sleep have so far not been fully investigated in healthy elderly cohorts, nor tested in AD patients or other related dementias. The manuscript discusses the role of sleep in normal and pathological aging, reviewing available evidence of NiBS applications during both wakefulness and sleep in healthy elderly individuals as well as in MCI/AD patients. Rationale and details for potential future brain stimulation studies targeting sleep alterations in the aging brain are discussed, including enhancement of cognitive performance, overall quality of life as well as protein clearance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.