ArticlePloS one2020
Smoking-by-genotype interaction in type 2 diabetes risk and fasting glucose.
Open access · goldAbstract read
In one paragraph
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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9citing papers in PubMed, 2 pooled it
6.5field-weighted citation impact, top 3% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Effect of TCF7L2 on the relationship between lifestyle factors and glycemic parameters: a systematic review.Nutrition journal · 2022Pooled it
- Lifestyle Risk Score: handling missingness of individual lifestyle components in meta-analysis of gene-by-lifestyle interactions.European journal of human genetics : EJHG · 2021Pooled it
- Polygenic risk score for type 2 diabetes shows context-dependent effects across populations.Nature communications · 2025Article
- Identification of gene-sex hormone interactions associated with type 2 diabetes among men and women.PLoS genetics · 2025Article
- Type 2 Diabetes Polygenic Risk Score Interactions with Lifestyle Risk Factors in Black Americans.Lifestyle genomics · 2025Article
- Genetic risk scores: are they important for diabetes management? results from multiple cross-sectional studies.Diabetology & metabolic syndrome · 2023Article
- Genes, environment, and African ancestry in cardiometabolic disorders.Trends in endocrinology and metabolism: TEM · 2023Review
- Leveraging family history in genetic association analyses of binary traits.BMC genomics · 2022Article
- Interactive Effect ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
Corrections and comments
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Authors and funding
58 authors at 20 institutions in 5 countries.
Peitao WuDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, MA, United States of America.
Denis RybinDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, MA, United States of America.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, United States of America.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, United States of America.
Nora FranceschiniUniversity of North Carolina, Chapel Hill, NC, United States of America.
Yize LiDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America.ORCID 0000-0003-1074-281X
Yingchang LuThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Jonathan MartenMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.ORCID 0000-0001-6916-2014
Solomon K MusaniJackson Heart Study, University of Mississippi Medical Center, MS, United States of America.
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Sridharan RaghavanSection of Hospital Medicine, Veterans Affairs Eastern Colorado Healthcare System, Denver, CO, United States of America.ORCID 0000-0003-0643-4873
Lynda M RoseDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States of America.
Karen SchwanderDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Albert V SmithIcelandic Heart Association, Kopavogur, Iceland.
Salman M TajuddinLaboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States of America.
Dina VojinovicDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Donna K ArnettDean's Office, University of Kentucky College of Public Health, Lexington, Kentucky, United States of America.
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Ayse DemirkanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jose C FlorezDiabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Massachusetts General Hospital, Boston, MA, United States of America.
Mohsen GhanbariDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0002-9476-7143
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, United States of America.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, United States of America.
Jingmin LiuDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.
Jun LiuDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-5288-3042
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Alison D MurrayThe Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, United Kingdom.
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, United States of America.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, United States of America.
André G UitterlindenDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.
Trudy VoortmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-2830-6813
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States of America.ORCID 0000-0002-0048-491X
Daniel ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States of America.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, United States of America.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Michele K EvansLaboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States of America.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, Iceland.
Caroline HaywardMRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Linda KaoDepartment of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, United States of America.
Sharon L R KardiaDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, United States of America.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.
Michael M ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, United States of America.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, United States of America.
Susan RedlineHarvard Medical School, Boston, MA, United States of America.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States of America.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States of America.
David SiscovickThe New York Academy of Medicine, New York, NY, United States of America.
Blair H SmithDivision of Population Health and Genomics, University of Dundee, Dundee, United Kingdom.
Cornelia van DuijnDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Alan B ZondermanLaboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States of America.
D C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO, United States of America.
James G WilsonDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, United States of America.
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, MA, United States of America.ORCID 0000-0003-2871-3603
James B MeigsPrograms in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, United States of America.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, MA, United States of America.
Jason L VassyDepartment of Medicine, Harvard Medical School, Boston, MA, United States of America.ORCID 0000-0001-6113-5564
Erasmus MC · NLNational Institutes of Health · USBoston University · USBrigham and Women's Hospital · USJackson Memorial Hospital · USLeiden University Medical Center · NLUniversity of Michigan · USWashington University in St. Louis · USBroad Institute · USIcahn School of Medicine at Mount Sinai · USInstitute of Genetics and Cancer · GBPennington Biomedical Research Center · USUniversity of Iceland · ISChild Health and Development Institute · USFred Hutch Cancer Center · USHarvard University · USJohns Hopkins University · USMashhad University of Medical Sciences · IRNew York Academy of Medicine · USOutcomes Research Consortium · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MInstitute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MHYPERGEN: GENETICS OF LEFT VENTRICULAR HYPERTROPHYR01HL055673 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 1996 to 2016
$18.1MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MThe Underlying Biology of Health DisparitiesZIAAG000519 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2009 to 2025
$15.7MSNP HEALTH ASSOCIATION RESOURCE (SHARE)N02HL64278 · NHLBI · PI CHIN, SIANG · 2007 to 2007
$9.2MA Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular TraitsR01HL118305 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 2014 to 2017
$8.3MChief Scientist Office CZD/16/6CSRD VA IK2 CX001262Intramural NIH HHS Z01 AG000513Medical Research Council MC_UU_00007/10NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NCI NIH HHS R01 CA047988NCI NIH HHS UM1 CA182913NHGRI NIH HHS R35 HG010706NHGRI NIH HHS U01 HG007417NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL64278NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL045670NHLBI NIH HHS R01 HL055673NHLBI NIH HHS R01 HL080467NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R21 HL123677NHLBI NIH HHS R21 HL140385NHLBI NIH HHS RC1 HL099355NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL054464NHLBI NIH HHS U01 HL054471NHLBI NIH HHS U01 HL054472NHLBI NIH HHS U01 HL054473NHLBI NIH HHS U01 HL054481NHLBI NIH HHS U01 HL054495NHLBI NIH HHS U01 HL054496NHLBI NIH HHS U01 HL054497NHLBI NIH HHS U01 HL054509NHLBI NIH HHS U10 HL054457NHLBI NIH HHS U10 HL054464NHLBI NIH HHS U10 HL054471NHLBI NIH HHS U10 HL054472NHLBI NIH HHS U10 HL054473NHLBI NIH HHS U10 HL054481NHLBI NIH HHS U10 HL054495NHLBI NIH HHS U10 HL054496NHLBI NIH HHS U10 HL054497NHLBI NIH HHS U10 HL054509NIA NIH HHS HHSN271201100004CNIA NIH HHS N01 AG012100NIDDK NIH HHS K24 DK080140NIDDK NIH HHS K24 DK110550NIDDK NIH HHS L30 DK089597NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK089256NIDDK NIH HHS R01 DK101855NIDDK NIH HHS R01 DK107786NIDDK NIH HHS R01 DK110113NIDDK NIH HHS R01 DK117445NIDDK NIH HHS R56 DK104806NIDDK NIH HHS U01 DK078616NIDDK NIH HHS UM1 DK078616NIMHD NIH HHS R01 MD012765Wellcome TrustWellcome Trust 104036/Z/14/ZWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
Abstract
Smoking is a potentially causal behavioral risk factor for type 2 diabetes (T2D), but not all smokers develop T2D. It is unknown whether genetic factors partially explain this variation. We performed genome-environment-wide interaction studies to identify loci exhibiting potential interaction with baseline smoking status (ever vs. never) on incident T2D and fasting glucose (FG). Analyses were performed in participants of European (EA) and African ancestry (AA) separately. Discovery analyses were conducted using genotype data from the 50,000-single-nucleotide polymorphism (SNP) ITMAT-Broad-CARe (IBC) array in 5 cohorts from from the Candidate Gene Association Resource Consortium (n = 23,189). Replication was performed in up to 16 studies from the Cohorts for Heart Aging Research in Genomic Epidemiology Consortium (n = 74,584). In meta-analysis of discovery and replication estimates, 5 SNPs met at least one criterion for potential interaction with smoking on incident T2D at p<1x10-7 (adjusted for multiple hypothesis-testing with the IBC array). Two SNPs had significant joint effects in the overall model and significant main effects only in one smoking stratum: rs140637 (FBN1) in AA individuals had a significant main effect only among smokers, and rs1444261 (closest gene C2orf63) in EA individuals had a significant main effect only among nonsmokers. Three additional SNPs were identified as having potential interaction by exhibiting a significant main effects only in smokers: rs1801232 (CUBN) in AA individuals, rs12243326 (TCF7L2) in EA individuals, and rs4132670 (TCF7L2) in EA individuals. No SNP met significance for potential interaction with smoking on baseline FG. The identification of these loci provides evidence for genetic interactions with smoking exposure that may explain some of the heterogeneity in the association between smoking and T2D.
Indexed as
GenotypeAdultAgedBlack PeopleBlood GlucoseCigarette SmokingCohort StudiesDiabetes Mellitus, Type 2FastingFeasibility StudiesFemaleGenetic LociGenome-Wide Association StudyHumansIncidenceMaleBlood Glucose
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