ArticlePloS one2020
Characterization of small, deeply located soft-tissue tumors: Conventional magnetic resonance imaging features and apparent diffusion coefficient for differentiation between non-malignancy and malignancy.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- MRI characteristics of plantar fibromas: a large consecutive series from a tertiary care center with symptom analysis.Skeletal radiology · 2026Article
- Magnetic Nanoparticle-Based High-Performance Positive and Negative Magnetic Resonance Imaging Contrast Agents.Pharmaceutics · 2023Review
- Diffusion-weighted imaging for the differentiation of Ewing sarcoma from osteosarcoma.Skeletal radiology · 2021Observational
- Diagnostic Performance of Diffusion MRI for differentiating Benign and Malignant Nonfatty Musculoskeletal Soft Tissue Tumors: A Systematic Review and Meta-analysis.Journal of Cancer · 2021Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesTo compare magnetic resonance imaging (MRI) parameters of small, deeply located non-malignant and malignant soft-tissue tumors (STTs).
methodsBetween May 2011 and December 2017, 95 MRIs in 95 patients with pathologically proven STTs of small size (<5 cm) and deep location (66 non-malignant and 29 malignant) were identified. For qualitative parameters, consensus reading was performed by three radiologists for presence of necrosis, infiltration, lobulation, and the tail sign. Apparent diffusion coefficient (ADC) was analyzed by two other radiologists independently. Univariable and multivariable analyses were performed to determine the diagnostic performances of MRI parameters in differentiating non-malignancy and malignancy, and for non-myxoid, non-hemosiderin STTs and myxoid STTs as subgroups. Interobserver agreement for ADC measurement was calculated with the intraclass correlation coefficient.
resultsInterobserver agreement on ADC measurement was almost perfect. On univariable analysis, the malignant group showed a significantly larger size, lower ADC, and higher incidence of all qualitative MRI parameters for all STTs. Size (p = 0.012, odds ratio [OR] 2.57), ADC (p = 0.041, OR 3.85), and the tail sign (p = 0.009, OR 6.47) were independently significant on multivariable analysis. For non-myxoid, non-hemosiderin STTs, age, size, ADC, frequency of infiltration, lobulation, and the tail sign showed significant differences between non-malignancy and malignancy on univariable analysis. Only ADC (p = 0.032, OR 142.86) retained its independence on multivariable analysis. For myxoid STTs, only size and tail sign were significant on univariable analysis without independent significance.
conclusionsSize, ADC, and incidence of qualitative MRI parameters were significantly different between small, deeply located non-malignant and malignant STTs. Only ADC was independently significant for both overall analysis and the non-myxoid, non-hemosiderin subgroup.
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