ArticlePloS one2020
trans-Zeatin-N-glucosides have biological activity in Arabidopsis thaliana.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Root-sourced 1-aminocyclopropane-1-carboxylic acid modulates development and adaptive responses to salinity in tomato.The Plant journal : for cell and molecular biology · 2026Article
- Chemically Induced Resistance to Pathogen Infection in Arabidopsis by Cytokinin (Trans-Zeatin) and an Aromatic Cytokinin Arabinoside.Molecular plant pathology · 2026Article
- Integrated analysis of physiological and metabolic data uncovers essential dynamic mechanisms involved in the maturation of cigar tobacco leaves.Scientific reports · 2024Article
- Zeatin: The 60th anniversary of its identification.Plant physiology · 2023Article
- Salicylic Acid Treatment and Its Effect on Seed Yield and Seed Molecular Composition ofInternational journal of molecular sciences · 2023Article
- The RPN12a proteasome subunit is essential for the multiple hormonal homeostasis controlling the progression of leaf senescence.Communications biology · 2022Article
- Interaction With Fungi Promotes the Accumulation of Specific Defense Molecules in Orchid Tubers and May Increase the Value of Tubers for Biotechnological and Medicinal Applications: The Case Study of Interaction BetweenFrontiers in plant science · 2022Article
- Delayed Leaf Senescence by Upregulation of Cytokinin Biosynthesis Specifically in Tomato Roots.Frontiers in plant science · 2022Article
- Differences in the Proteomic and Metabolomic Response ofFrontiers in microbiology · 2022Article
- The Omics Hunt for Novel Molecular Markers of Resistance toPlants (Basel, Switzerland) · 2021Article
- Integrating the Roles for Cytokinin and Auxin in De Novo Shoot Organogenesis: From Hormone Uptake to Signaling Outputs.International journal of molecular sciences · 2021Review
- Isopentenyltransferases as master regulators of crop performance: their function, manipulation, and genetic potential for stress adaptation and yield improvement.Plant biotechnology journal · 2021Review
- Cytokinin glucosyl transferases, key regulators of cytokinin homeostasis, have potential value for wheat improvement.Plant biotechnology journal · 2021Review
- The Hulks and the Deadpools of the Cytokinin Universe: A Dual Strategy for Cytokinin Production, Translocation, and Signal Transduction.Biomolecules · 2021Review
- CytokininBiomolecules · 2020Article
- Cytokinin isopentenyladenine and its glucoside isopentenyladenine-9G delay leaf senescence through activation of cytokinin-associated genes.Plant direct · 2020Article
- Arabidopsis Response to Inhibitor of Cytokinin Degradation INCYDE: Modulations of Cytokinin Signaling and Plant Proteome.Plants (Basel, Switzerland) · 2020Article
- Integrated Proteomic and Metabolomic Profiling ofInternational journal of molecular sciences · 2020Article
- Barley Root Proteome and Metabolome in Response to Cytokinin and Abiotic Stimuli.Frontiers in plant science · 2020Article
- AnFrontiers in plant science · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytokinin is an indispensable phytohormone responsible for physiological processes ranging from root development to leaf senescence. The term "cytokinin" refers to several dozen adenine-derived compounds occurring naturally in plants. Cytokinins (CKs) can be divided into various classes and forms; base forms are generally considered to be active while highly abundant cytokinin-N-glucosides (CKNGs), composed of a CK base irreversibly conjugated to a glucose molecule, are considered inactive. However, results from early CK studies suggest CKNGs do not always lack activity despite the perpetuation over several decades in the literature that they are inactive. Here we show that exogenous application of trans-Zeatin-N-glucosides (tZNGs, a specific class of CKNGs) to Arabidopsis results in CK response comparable to the application of an active CK base. These results are most apparent in senescence assays where both a CK base (tZ) and tZNGs (tZ7G, tZ9G) delay senescence in cotyledons. Further experiments involving root growth and shoot regeneration revealed tZNGs do not always have the same effects as tZ, and have largely distinct effects on the transcriptome and proteome. These data are in contrast to previous reports of CKNGs being inactive and raise questions about the function of these compounds as well as their mechanism of action.
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